Ethyl 4'-Hydroxy-3'-Methoxycinnamate (CAS 4046-02-0) Explained： A Deep Dive into Its Properties and Applications

Abstract

This article provides a comprehensive overview of Ethyl 4'-Hydroxy-3'-Methoxycinnamate (CAS 4046-02-0), a compound with a variety of properties and applications. It delves into its chemical structure, physical properties, synthesis methods, biological activities, and its uses in different industries. The article aims to offer a deep dive into the understanding of this compound, highlighting its significance in research and practical applications.

Introduction to Ethyl 4'-Hydroxy-3'-Methoxycinnamate (CAS 4046-02-0)

Ethyl 4'-Hydroxy-3'-Methoxycinnamate, also known as ethyl 4-hydroxy-3-methoxy cinnamate, is a derivative of cinnamic acid. It is a white to off-white crystalline solid that is widely used in various industries due to its unique properties. This compound is characterized by its aromatic ring structure, which includes a hydroxyl group and a methoxy group at the 4' and 3' positions, respectively.

Chemical Structure and Physical Properties

The chemical structure of Ethyl 4'-Hydroxy-3'-Methoxycinnamate consists of a benzene ring with a hydroxyl group and a methoxy group attached to the 4' and 3' positions. This structure contributes to its unique physical properties, such as its melting point, which is typically around 58-60°C. The compound is also soluble in organic solvents like ethanol and acetone but is sparingly soluble in water.

Synthesis Methods

Ethyl 4'-Hydroxy-3'-Methoxycinnamate can be synthesized through various methods, including the esterification of 4-hydroxy-3-methoxycinnamic acid with ethanol. This process involves the reaction of the carboxylic acid with ethanol in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid. Another method involves the reaction of 4-hydroxy-3-methoxycinnamic acid with methanol in the presence of a base catalyst, such as sodium hydroxide or potassium hydroxide.

Biological Activities

Ethyl 4'-Hydroxy-3'-Methoxycinnamate exhibits several biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. These activities are primarily attributed to the presence of the hydroxyl and methoxy groups in its structure. The compound has been shown to scavenge free radicals, which makes it a potential candidate for the development of antioxidants. Additionally, its anti-inflammatory properties make it a promising candidate for the treatment of inflammatory diseases.

Applications in Different Industries

The versatile properties of Ethyl 4'-Hydroxy-3'-Methoxycinnamate have led to its widespread use in various industries. In the pharmaceutical industry, it is used as an active ingredient in the development of drugs for the treatment of oxidative stress and inflammation. In the food industry, it is used as a food additive to enhance the shelf life of products by acting as an antioxidant. Moreover, it is used in the cosmetic industry as an ingredient in sunscreens and skin care products due to its UV-filtering properties.

Environmental Impact and Safety Considerations

While Ethyl 4'-Hydroxy-3'-Methoxycinnamate offers numerous benefits, it is important to consider its environmental impact and safety. The compound is considered to be biodegradable, but its persistence in the environment should be monitored. Additionally, it is classified as a low-toxicity compound, but proper handling and disposal practices are essential to minimize any potential risks.

Conclusion

In conclusion, Ethyl 4'-Hydroxy-3'-Methoxycinnamate (CAS 4046-02-0) is a versatile compound with a wide range of properties and applications. Its unique chemical structure contributes to its biological activities, making it a valuable compound in various industries. Understanding its synthesis methods, physical properties, and environmental impact is crucial for its safe and effective use. This article has provided a comprehensive overview of Ethyl 4'-Hydroxy-3'-Methoxycinnamate, highlighting its significance in research and practical applications.

Keywords

Ethyl 4'-Hydroxy-3'-Methoxycinnamate, CAS 4046-02-0, chemical structure, physical properties, synthesis methods, biological activities, applications, environmental impact, safety considerations.