4-Morpholineethanesulfonic Acid (CAS 4432-31-9)： Everything You Need to Know About This Compound

Abstract

This article provides an in-depth overview of 4-Morpholineethanesulfonic Acid (CAS 4432-31-9), a compound with significant applications in various industries. It covers its chemical properties, synthesis methods, uses, safety considerations, environmental impact, and regulatory information. By exploring these aspects, the article aims to offer a comprehensive understanding of this compound and its importance in modern chemistry.

Introduction to 4-Morpholineethanesulfonic Acid

4-Morpholineethanesulfonic Acid, also known as MES, is a sulfonic acid derivative of morpholine. It is a colorless to pale yellow crystalline solid that is soluble in water and organic solvents. MES is widely used in various applications due to its unique chemical properties. This section will delve into the chemical structure, physical properties, and molecular formula of MES.

Chemical Structure and Physical Properties

The chemical structure of MES consists of a morpholine ring with an ethyl group and a sulfonic acid group attached to the nitrogen atom. The molecular formula of MES is C₅H₁₁NOS, and its molecular weight is 151.19 g/mol. MES is a solid at room temperature and has a melting point of approximately 234-236°C. It is also highly soluble in water, with a solubility of around 100 g/100 mL at 20°C. The compound is slightly soluble in organic solvents such as methanol and ethanol.

Synthesis Methods

The synthesis of MES can be achieved through various methods, including the reaction of morpholine with ethyl chlorosulfonic acid, the reaction of morpholine with ethyl sulfate, and the reaction of morpholine with ethyl bisulfate. Each method has its advantages and limitations, and the choice of synthesis route depends on factors such as cost, yield, and environmental considerations.

Applications of 4-Morpholineethanesulfonic Acid

MES finds extensive use in various industries, including pharmaceuticals, agriculture, and chemical manufacturing. In the pharmaceutical industry, MES is used as a buffering agent in the formulation of drugs, as it helps maintain a stable pH level. In agriculture, MES is used as a herbicide and as a plant growth regulator. Additionally, MES is employed in the production of detergents, textiles, and as a catalyst in organic synthesis.

Safety Considerations

Like any chemical compound, 4-Morpholineethanesulfonic Acid has certain safety considerations. It is important to handle MES with care, as it can cause irritation to the skin, eyes, and respiratory system. Proper personal protective equipment, such as gloves, goggles, and a respirator, should be worn when handling MES. In case of accidental exposure, immediate medical attention should be sought.

Environmental Impact

The environmental impact of MES is a subject of concern. The compound is considered moderately toxic to aquatic life and can persist in the environment. Therefore, proper waste management and disposal practices are essential to minimize the environmental impact of MES. It is also important to consider the potential for bioaccumulation and the long-term effects on ecosystems.

Regulatory Information

4-Morpholineethanesulfonic Acid is subject to various regulations and standards, depending on its use and the country in which it is produced or sold. In the United States, the Environmental Protection Agency (EPA) regulates the use of MES, and it is classified as a hazardous substance. In the European Union, MES is subject to the REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals) regulation, which requires manufacturers and importers to register the substance.

Conclusion

4-Morpholineethanesulfonic Acid (CAS 4432-31-9) is a versatile compound with a wide range of applications. Its chemical properties, synthesis methods, uses, safety considerations, environmental impact, and regulatory information are crucial aspects to understand for anyone involved in its production, handling, or use. By providing a comprehensive overview of MES, this article aims to contribute to the knowledge base in the field of chemistry and its applications.

Keywords

4-Morpholineethanesulfonic Acid, MES, CAS 4432-31-9, chemical properties, synthesis, applications, safety, environmental impact, regulatory information