4-Methylbenzophenone CAS 134-84-9： Everything You Need to Know About This Chemical

Abstract

This article provides an in-depth overview of 4-Methylbenzophenone, a chemical compound with the CAS number 134-84-9. It covers its physical and chemical properties, synthesis methods, applications in various industries, health and safety considerations, and regulatory status. The aim is to offer a comprehensive understanding of this compound, its uses, and its implications in both industrial and research settings.

Introduction to 4-Methylbenzophenone

4-Methylbenzophenone, also known as 4-methylbenzophenone, is a colorless to pale yellow crystalline solid with a melting point of approximately 47-49°C. It is a derivative of benzophenone, where a methyl group is attached to the benzene ring. This compound is widely used in the synthesis of dyes, pharmaceuticals, and other chemicals. In this article, we will explore the various aspects of 4-methylbenzophenone, including its physical properties, synthesis, applications, and safety considerations.

Physical and Chemical Properties

4-Methylbenzophenone has a molecular formula of C13H10O and a molecular weight of 182.21 g/mol. It is a non-polar compound with a boiling point of around 265-267°C. The compound is soluble in organic solvents such as ethanol, ether, and acetone but is insoluble in water. Its chemical structure allows it to undergo various reactions, including nucleophilic addition, electrophilic aromatic substitution, and oxidation reactions.

Synthesis Methods

The synthesis of 4-methylbenzophenone can be achieved through several methods, including the Grignard reaction, the Friedel-Crafts acylation, and the reaction of benzophenone with methyl chloride. The Grignard reaction involves the reaction of a Grignard reagent with benzophenone, while the Friedel-Crafts acylation uses an acyl chloride or anhydride in the presence of a catalyst. The reaction of benzophenone with methyl chloride is a straightforward method that yields the desired product in good yield.

Applications in Industry

4-Methylbenzophenone finds extensive use in the chemical industry, particularly in the production of dyes and pigments. It is a key intermediate in the synthesis of various azo dyes, which are widely used in textiles, plastics, and paints. Additionally, it is employed in the manufacturing of pharmaceuticals, where it serves as a precursor for certain drugs. Moreover, its use in perfumery is notable, as it contributes to the fragrance profile of various products.

Health and Safety Considerations

Handling 4-methylbenzophenone requires caution due to its potential health risks. The compound is toxic if inhaled, ingested, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory system. Therefore, appropriate personal protective equipment (PPE) should be worn when working with this chemical. Proper ventilation and adherence to safety protocols are essential to minimize exposure risks.

Regulatory Status

4-Methylbenzophenone is subject to regulations in many countries due to its potential environmental and health hazards. It is classified as a hazardous substance under various regulations, including the European Union's Classification, Labelling, and Packaging (CLP) Regulation. Compliance with these regulations is crucial for manufacturers, distributors, and users of the compound.

Conclusion

4-Methylbenzophenone, with its unique chemical properties and versatile applications, plays a significant role in various industries. This article has provided an extensive overview of the compound, covering its physical and chemical properties, synthesis methods, industrial applications, health and safety considerations, and regulatory status. Understanding these aspects is vital for anyone involved in the handling, manufacturing, or research of 4-methylbenzophenone.

Keywords

4-Methylbenzophenone, CAS 134-84-9, benzophenone derivative, synthesis, applications, health and safety, regulatory status