N-Hydroxyethyl Piperidine (CAS 3040-44-6)： What You Need to Know About This Molecule

Abstract

This article provides an in-depth overview of N-Hydroxyethyl Piperidine (CAS 3040-44-6), a molecule with significant implications in various scientific and industrial applications. It delves into the chemical structure, synthesis methods, biological activities, potential applications, safety considerations, and regulatory aspects of this compound. By exploring these facets, the article aims to offer a comprehensive understanding of N-Hydroxyethyl Piperidine and its relevance in modern chemistry.

Introduction to N-Hydroxyethyl Piperidine (CAS 3040-44-6)

N-Hydroxyethyl Piperidine, also known as 1-(2-hydroxyethyl)piperidine, is a synthetic organic compound with the chemical formula C₇H₁₅N₂O. It is a derivative of piperidine, a cyclic amine, with an ethyl group attached to the nitrogen atom. This molecule has gained attention due to its unique chemical properties and potential applications in pharmaceuticals, agrochemicals, and other industries.

Chemical Structure and Properties

The chemical structure of N-Hydroxyethyl Piperidine consists of a piperidine ring with an ethyl group and a hydroxyl group attached to the nitrogen atom. This structure contributes to its basic nature, making it a potential nucleophile in various chemical reactions. The presence of the hydroxyl group also allows for the possibility of forming hydrogen bonds, which can influence its solubility and biological activity.

The molecular weight of N-Hydroxyethyl Piperidine is 137.21 g/mol, and it has a melting point of approximately 60-62°C. It is a colorless to pale yellow liquid with a characteristic odor. The compound is soluble in water, alcohol, and ether, which makes it versatile for various applications.

Synthesis Methods

The synthesis of N-Hydroxyethyl Piperidine can be achieved through several methods, including the reaction of piperidine with ethyl chlorohydrin and the condensation of piperidine with formaldehyde and ethylene glycol. These methods involve the formation of a cyclic ether intermediate, which is then hydrolyzed to yield the desired compound.

The reaction of piperidine with ethyl chlorohydrin is a straightforward synthesis route that yields high purity N-Hydroxyethyl Piperidine. This method involves the addition of ethyl chlorohydrin to piperidine in the presence of a base, followed by hydrolysis to remove the chloro group. The resulting compound is then purified through recrystallization or distillation.

Biological Activities

N-Hydroxyethyl Piperidine has been investigated for its potential biological activities, including its effects on the central nervous system, cardiovascular system, and immune system. Studies have shown that this compound can act as a serotonin receptor antagonist, which may have implications in the treatment of psychiatric disorders.

In addition, N-Hydroxyethyl Piperidine has been found to possess anti-inflammatory and analgesic properties. This suggests its potential use in the development of new therapeutic agents for the treatment of inflammatory diseases and chronic pain conditions.

Potential Applications

The unique properties of N-Hydroxyethyl Piperidine make it a valuable compound in various applications. In the pharmaceutical industry, it has the potential to be used as a starting material for the synthesis of new drugs. Its serotonin receptor antagonist activity could be exploited in the development of antidepressants and anxiolytics.

In agrochemicals, N-Hydroxyethyl Piperidine could be used as a herbicide or insecticide due to its potential to disrupt the nervous system of pests. Its anti-inflammatory properties may also make it useful in the development of new crop protection agents.

Safety Considerations

As with any chemical compound, N-Hydroxyethyl Piperidine has safety considerations that must be taken into account. The compound is toxic if ingested, inhaled, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory system. Therefore, appropriate safety measures, such as the use of personal protective equipment and proper handling procedures, are essential when working with this compound.

The acute toxicity of N-Hydroxyethyl Piperidine has been evaluated in animal studies, and it has been found to have a moderate toxicity profile. However, long-term exposure to the compound has not been extensively studied, and further research is needed to assess its potential chronic toxicity.

Regulatory Aspects

N-Hydroxyethyl Piperidine is subject to regulatory control in many countries. Its production, import, and export are governed by various laws and regulations, including the Chemicals (Amendment) Regulations 2002 in the United Kingdom and the Toxic Substances Control Act in the United States.

These regulations are in place to ensure the safe handling and use of the compound and to protect human health and the environment. Compliance with these regulations is essential for any organization involved in the production, distribution, or use of N-Hydroxyethyl Piperidine.

Conclusion

In conclusion, N-Hydroxyethyl Piperidine (CAS 3040-44-6) is a versatile molecule with significant implications in various scientific and industrial applications. Its unique chemical structure, synthesis methods, biological activities, potential applications, safety considerations, and regulatory aspects make it a subject of interest in modern chemistry. By understanding these facets, researchers and industry professionals can make informed decisions regarding the use and development of this compound.

Keywords: N-Hydroxyethyl Piperidine, CAS 3040-44-6, chemical structure, synthesis, biological activities, potential applications, safety considerations, regulatory aspects