Unlock the Secrets of 2,2',4,4'-Tetrahydroxybenzophenone CAS 131-55-5： A Comprehensive Guide

Abstract

This comprehensive guide delves into the mysteries of 2,2',4,4'-Tetrahydroxybenzophenone, a compound with the CAS number 131-55-5. The article explores its chemical properties, synthesis methods, applications, health and environmental impacts, and the latest research findings. By unraveling the secrets of this compound, readers gain a deeper understanding of its significance in various fields, from pharmaceuticals to environmental science.

Introduction to 2,2',4,4'-Tetrahydroxybenzophenone

2,2',4,4'-Tetrahydroxybenzophenone, commonly known as THBP, is a benzophenone derivative characterized by four hydroxyl groups attached to the benzene ring. It is a white crystalline solid with a melting point of 135-136°C. THBP is widely used in various industries due to its unique properties, such as its ability to act as a UV absorber, antioxidant, and preservative.

Chemical Properties of 2,2',4,4'-Tetrahydroxybenzophenone

The chemical structure of THBP plays a crucial role in determining its properties. The presence of four hydroxyl groups makes it highly polar, which affects its solubility and reactivity. THBP is soluble in polar solvents like water, alcohol, and acetone, but it is insoluble in non-polar solvents like hexane and ether. The compound is also susceptible to oxidation, which can lead to the formation of colored by-products.

Synthesis of 2,2',4,4'-Tetrahydroxybenzophenone

The synthesis of THBP involves various methods, including the Knoevenagel condensation, the Doebner-Miller reaction, and the Stille coupling. The Knoevenagel condensation method involves the reaction of a β-ketoester with an aromatic aldehyde in the presence of a base, followed by hydrolysis to obtain THBP. The Doebner-Miller reaction utilizes a diazoketone and an aromatic aldehyde to synthesize THBP. The Stille coupling method involves the reaction of a boronic acid with a phenyl acetylene in the presence of a palladium catalyst.

Applications of 2,2',4,4'-Tetrahydroxybenzophenone

THBP finds extensive applications in various industries. In the pharmaceutical industry, it is used as an antioxidant and preservative in drugs and cosmetics. In the food industry, it acts as a UV absorber and antioxidant in food packaging materials. Additionally, THBP is used in the production of dyes, pigments, and photographic materials.

Health and Environmental Impacts of 2,2',4,4'-Tetrahydroxybenzophenone

The use of THBP in various products raises concerns about its health and environmental impacts. Studies have shown that THBP can be toxic to aquatic organisms, leading to bioaccumulation in the food chain. In humans, exposure to high levels of THBP may cause skin irritation, allergic reactions, and respiratory problems. However, the compound is generally considered safe for use in low concentrations.

Latest Research Findings on 2,2',4,4'-Tetrahydroxybenzophenone

Recent research has focused on the development of novel synthesis methods for THBP, as well as the exploration of its potential applications in new fields. One such application is the use of THBP as a catalyst in organic synthesis. Additionally, researchers are investigating the compound's potential as a therapeutic agent for various diseases, including cancer and neurodegenerative disorders.

Conclusion

Unlocking the secrets of 2,2',4,4'-Tetrahydroxybenzophenone, a compound with the CAS number 131-55-5, has provided valuable insights into its chemical properties, synthesis methods, applications, and health and environmental impacts. As research continues to unfold, the significance of THBP in various fields is expected to grow, offering new opportunities for innovation and development.

Keywords: 2,2',4,4'-Tetrahydroxybenzophenone, THBP, CAS 131-55-5, chemical properties, synthesis, applications, health impacts, environmental impacts, research findings