2'-Deoxy-2'-Fluoro-2'-C-Methyluridine (CAS 863329-66-2) - Everything You Need to Know About This Compound

Abstract

This article provides an in-depth overview of 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine (CAS 863329-66-2), a compound with significant implications in various scientific fields. The article delves into its chemical structure, biological significance, synthesis methods, applications, potential risks, and regulatory status, offering a comprehensive understanding of this compound.

Introduction to 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine (CAS 863329-66-2)

2'-Deoxy-2'-Fluoro-2'-C-Methyluridine, also known as FCMU, is a modified nucleoside that has garnered attention due to its unique chemical properties and potential applications in research and medicine. This compound is a derivative of uridine, a naturally occurring nucleoside found in RNA and DNA. The modification involves the introduction of a fluorine atom at the 2'-position and a methyl group at the 2'-carbon, which alters the compound's behavior and potential uses.

Chemical Structure and Properties

The chemical structure of 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine is characterized by the presence of a deoxyribose sugar, a uracil base, and the aforementioned modifications. The fluorine atom at the 2'-position increases the compound's resistance to nucleases, making it more stable in biological systems. Additionally, the methyl group at the 2'-carbon can affect the compound's interaction with cellular receptors and enzymes.

Biological Significance

FCMU has been studied for its potential applications in various biological processes. Its stability and modified structure make it a valuable tool in molecular biology research, particularly in the study of RNA and DNA metabolism. FCMU has been used as a substrate for the synthesis of nucleic acids and as a probe to study the function of nucleases and other enzymes involved in nucleic acid processing.

Synthesis Methods

The synthesis of 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine involves several steps, including the preparation of the deoxyribose sugar, the uracil base, and the introduction of the fluorine and methyl groups. The synthesis can be achieved through various methods, such as chemical synthesis, enzymatic synthesis, and solid-phase synthesis. Each method has its advantages and limitations, and the choice of synthesis route depends on the desired purity and scale of production.

Applications

FCMU has several applications in research and medicine. In the field of molecular biology, it is used as a substrate for the synthesis of nucleic acids, as a probe for studying nucleases, and as a tool for modifying DNA and RNA. In medicine, FCMU has shown potential in the development of antiviral drugs and as a component in gene therapy vectors.

Potential Risks

While FCMU has many potential benefits, it also poses certain risks. The compound's modified structure may lead to unexpected interactions with cellular components, and its stability could potentially cause accumulation in tissues. Additionally, the use of FCMU in medical applications requires careful consideration of its potential side effects and toxicity.

Regulatory Status

The regulatory status of 2'-Deoxy-2'-Fluoro-2'-C-Methyluridine varies by country and application. In some regions, the compound is regulated as a research chemical, while in others, it may be subject to stricter controls due to its potential medical applications. Understanding the regulatory status is crucial for researchers and manufacturers to ensure compliance with local laws and regulations.

Conclusion

2'-Deoxy-2'-Fluoro-2'-C-Methyluridine (CAS 863329-66-2) is a compound with a unique chemical structure and significant potential in various scientific fields. Its stability, modified structure, and potential applications make it a valuable tool in molecular biology research and medicine. However, the compound also poses certain risks and requires careful consideration of its regulatory status. This article has provided a comprehensive overview of FCMU, covering its chemical properties, biological significance, synthesis methods, applications, potential risks, and regulatory status.

Keywords

2'-Deoxy-2'-Fluoro-2'-C-Methyluridine, FCMU, nucleoside, uridine, modification, synthesis, application, risk, regulation