The Most Comprehensive Resource on Tetrafluoroterephthalonitrile (CAS 1835-49-0) Properties and Uses

Abstract

This article provides a comprehensive overview of tetrafluoroterephthalonitrile (CAS 1835-49-0), a chemical compound with significant properties and applications. It delves into the physical and chemical properties, synthesis methods, industrial uses, environmental impact, safety considerations, and regulatory aspects of tetrafluoroterephthalonitrile. The aim is to offer a detailed resource for understanding the multifaceted nature of this compound.

Introduction to Tetrafluoroterephthalonitrile (CAS 1835-49-0)

Tetrafluoroterephthalonitrile, also known as 4,4'-difluoro-2,2'-difluoro-1,3-dicyanobenzophenone, is a chemical compound with the molecular formula C14H4F4N2O. It is a colorless solid that is highly flammable and toxic. Tetrafluoroterephthalonitrile finds applications in various industries, including pharmaceuticals, agrochemicals, and specialty chemicals. This article aims to provide an in-depth analysis of its properties and uses.

Physical and Chemical Properties

Tetrafluoroterephthalonitrile is a colorless solid with a melting point of approximately 110-112°C. It is highly flammable and has a vapor pressure of 0.013 mmHg at 25°C. The compound is soluble in organic solvents such as acetone, chloroform, and methylene chloride but is insoluble in water. Its chemical structure consists of a benzophenone core with two fluorine atoms and two cyano groups attached to the aromatic rings.

The high fluorination of tetrafluoroterephthalonitrile makes it resistant to degradation by many chemicals and environmental factors. However, it is also highly reactive, especially under conditions of heat and light, which can lead to the formation of toxic by-products.

Synthesis Methods

The synthesis of tetrafluoroterephthalonitrile involves several steps, including the preparation of the intermediate compounds. One common method involves the reaction of 4,4'-difluoro-2,2'-difluoro-1,3-dicyanobenzophenone with a suitable nucleophile to form the desired compound. Another method involves the cyclization of a diacylhydrazine derivative followed by fluorination.

The synthesis process requires careful control of reaction conditions to ensure the desired product is obtained with high purity. The use of catalysts and solvents can also influence the yield and purity of the final product.

Industrial Uses

Tetrafluoroterephthalonitrile is used in various industrial applications, primarily in the pharmaceutical and agrochemical sectors. It serves as an intermediate in the synthesis of pharmaceuticals, including antiviral and anticancer agents. In agrochemicals, it is used in the production of herbicides and insecticides.

The unique properties of tetrafluoroterephthalonitrile, such as its high thermal stability and resistance to degradation, make it an attractive starting material for the development of new chemical compounds with improved performance.

Environmental Impact

The environmental impact of tetrafluoroterephthalonitrile is a concern due to its potential toxicity and persistence in the environment. The compound is classified as a hazardous substance, and its release into the environment can lead to adverse effects on aquatic life and soil ecosystems.

Efforts are being made to minimize the environmental impact of tetrafluoroterephthalonitrile through the development of safer synthesis methods and the implementation of proper waste management practices. Additionally, research is ongoing to assess the long-term effects of the compound on the environment.

Safety Considerations

Handling tetrafluoroterephthalonitrile requires strict adherence to safety protocols due to its toxic and flammable nature. Personal protective equipment, such as gloves, goggles, and lab coats, should be worn when working with the compound. Proper ventilation is also essential to prevent the accumulation of toxic vapors.

In case of accidental exposure, immediate medical attention should be sought. Tetrafluoroterephthalonitrile can cause severe irritation to the eyes, skin, and respiratory system. It is also toxic if ingested or inhaled.

Regulatory Aspects

Tetrafluoroterephthalonitrile is subject to various regulations and guidelines, including those related to its production, use, and disposal. These regulations are designed to protect human health and the environment. Compliance with these regulations is mandatory for manufacturers, users, and handlers of the compound.

The regulatory landscape for tetrafluoroterephthalonitrile is continually evolving, with new regulations being introduced to address emerging concerns. Staying informed about these regulations is crucial for ensuring compliance and minimizing risks associated with the compound.

Conclusion

Tetrafluoroterephthalonitrile (CAS 1835-49-0) is a chemical compound with a range of properties and applications that make it valuable in various industries. This article has provided a comprehensive overview of its physical and chemical properties, synthesis methods, industrial uses, environmental impact, safety considerations, and regulatory aspects. Understanding these factors is essential for the safe and responsible use of tetrafluoroterephthalonitrile and for minimizing its potential risks.

Keywords: Tetrafluoroterephthalonitrile, CAS 1835-49-0, properties, uses, synthesis, environmental impact, safety, regulations