N-Methyl-N-Benzylaniline CAS 614-30-2： Everything You Need to Know About This Chemical

Abstract

This article provides an in-depth overview of N-Methyl-N-Benzylaniline, a chemical compound with the CAS number 614-30-2. It covers its chemical properties, synthesis methods, applications, safety considerations, environmental impact, and regulatory status. By exploring these aspects, the article aims to offer a comprehensive understanding of this chemical and its significance in various industries.

Introduction to N-Methyl-N-Benzylaniline

N-Methyl-N-Benzylaniline, also known as benzylmethylamine, is an organic compound with the molecular formula C₈H₉N. It is a colorless to pale yellow liquid with a characteristic odor. This compound is widely used in the synthesis of pharmaceuticals, dyes, and other organic compounds. In this article, we will delve into the various aspects of N-Methyl-N-Benzylaniline, including its chemical properties, synthesis, applications, safety, and environmental impact.

Chemical Properties of N-Methyl-N-Benzylaniline

N-Methyl-N-Benzylaniline is a primary amine, which means it contains a nitrogen atom bonded to one hydrogen atom and two carbon atoms. The benzyl group (-C₆H₅) is attached to the nitrogen atom, making it a benzylamine derivative. The compound has a melting point of approximately 14-16°C and a boiling point of around 212-214°C. It is soluble in organic solvents such as ethanol, ether, and chloroform but is only slightly soluble in water.

The chemical structure of N-Methyl-N-Benzylaniline allows it to participate in various chemical reactions, including nucleophilic substitution, condensation, and cyclization reactions. These reactions are crucial in the synthesis of pharmaceuticals, dyes, and other organic compounds.

Synthesis of N-Methyl-N-Benzylaniline

The synthesis of N-Methyl-N-Benzylaniline can be achieved through several methods, including the reaction of benzyl chloride with methylamine, the reaction of benzyl alcohol with formaldehyde and ammonia, and the reaction of benzyl alcohol with chloromethane. Each method has its advantages and limitations, and the choice of synthesis route depends on the desired purity, yield, and cost-effectiveness.

The most common method involves the reaction of benzyl chloride with methylamine in the presence of a base, such as sodium hydroxide or potassium hydroxide. This reaction is known as the amine displacement reaction and results in the formation of N-Methyl-N-Benzylaniline and hydrochloride salt. The reaction is typically carried out in an aqueous solution at room temperature.

Applications of N-Methyl-N-Benzylaniline

N-Methyl-N-Benzylaniline finds extensive use in the pharmaceutical industry for the synthesis of various drugs, including analgesics, antipyretics, and cardiovascular agents. It is also used in the production of dyes, particularly in the textile industry, where it contributes to the vibrant colors of fabrics.

In addition to these applications, N-Methyl-N-Benzylaniline is used in the synthesis of organic intermediates, such as benzyl alcohols and benzyl ethers. These intermediates are further utilized in the production of fragrances, plastics, and other chemicals.

Safety Considerations

N-Methyl-N-Benzylaniline is considered a hazardous chemical due to its potential for causing irritation to the skin, eyes, and respiratory system. It is also toxic if ingested or inhaled. Therefore, appropriate safety measures must be taken when handling this compound, including the use of personal protective equipment (PPE) and proper ventilation.

Workers exposed to N-Methyl-N-Benzylaniline should be trained on the safe handling and disposal of the chemical. In case of accidental exposure, immediate medical attention should be sought.

Environmental Impact

The environmental impact of N-Methyl-N-Benzylaniline is primarily related to its potential for bioaccumulation and persistence in the environment. The compound can be found in wastewater and soil, where it may persist for an extended period. This persistence can lead to ecological imbalances and adverse effects on aquatic life.

To mitigate the environmental impact, proper waste management and treatment processes are essential. Additionally, the use of alternative, less harmful chemicals should be considered whenever possible.

Regulatory Status

N-Methyl-N-Benzylaniline is subject to various regulations and guidelines, including those related to its production, use, and disposal. These regulations are designed to protect human health and the environment. Compliance with these regulations is mandatory for manufacturers, users, and handlers of the chemical.

The European Chemicals Agency (ECHA) and the United States Environmental Protection Agency (EPA) are among the regulatory bodies that oversee the use and handling of N-Methyl-N-Benzylaniline. Compliance with these regulations is crucial for ensuring the safe and responsible use of the chemical.

Conclusion

N-Methyl-N-Benzylaniline, with the CAS number 614-30-2, is a versatile organic compound with a wide range of applications in the pharmaceutical, dye, and chemical industries. This article has provided an overview of its chemical properties, synthesis methods, applications, safety considerations, environmental impact, and regulatory status. Understanding these aspects is essential for the safe and responsible use of N-Methyl-N-Benzylaniline in various industrial processes.

Keywords: N-Methyl-N-Benzylaniline, CAS 614-30-2, benzylmethylamine, synthesis, applications, safety, environmental impact, regulatory status.