The Must-Know Facts About 2-Anilinoethanol (CAS 122-98-5) for Researchers

Abstract

This article provides an in-depth overview of the essential facts about 2-Anilinoethanol (CAS 122-98-5), a compound of significant interest to researchers in various scientific fields. It covers the chemical properties, synthesis methods, applications, safety considerations, and regulatory aspects of this compound, offering a comprehensive guide for scientists and researchers working with 2-Anilinoethanol.

Introduction to 2-Anilinoethanol (CAS 122-98-5)

2-Anilinoethanol, also known as N-phenylethylamine, is a chemical compound with the molecular formula C₈H₁₀N. It is a colorless to pale yellow liquid with a characteristic odor. This compound is widely used in organic synthesis, pharmaceuticals, and agrochemicals. Its unique properties make it a valuable tool in research and development.

Chemical Properties

2-Anilinoethanol is a primary amine, which means it contains a nitrogen atom bonded to two hydrogen atoms and one alkyl or aryl group. The presence of the anilino group (phenylamine) gives it distinct chemical properties. It is soluble in water, alcohol, and ether, and it can undergo various chemical reactions, such as nucleophilic substitution, condensation, and cyclization.

Synthesis Methods

The synthesis of 2-Anilinoethanol can be achieved through several methods, including the reaction of aniline with ethyl halide or alkyl halide in the presence of a base. Another common method involves the reduction of N-phenylethylamine nitrate or nitrite using a reducing agent like sodium borohydride. The choice of synthesis method often depends on the scale of production and the desired purity of the compound.

Applications in Organic Synthesis

2-Anilinoethanol is a versatile intermediate in organic synthesis. It is used to synthesize various compounds, including pharmaceuticals, agrochemicals, and dyes. For instance, it can be used to synthesize the antiviral drug acyclovir and the herbicide paraquat. Its ability to undergo various chemical transformations makes it a valuable building block in the synthesis of complex molecules.

Use in Pharmaceuticals

In the pharmaceutical industry, 2-Anilinoethanol serves as a precursor for the synthesis of several drugs. Its unique chemical properties allow it to be involved in the synthesis of compounds with diverse pharmacological activities. For example, it is used in the synthesis of antiviral agents, analgesics, and anti-inflammatory drugs.

Agrochemical Applications

2-Anilinoethanol is also used in the agrochemical industry. It is a key intermediate in the synthesis of herbicides, fungicides, and insecticides. Its ability to undergo various chemical reactions makes it a valuable compound for developing new agrochemicals that can effectively control pests and diseases in agricultural crops.

Safety Considerations

Handling 2-Anilinoethanol requires caution due to its potential toxicity. It is classified as a hazardous substance, and exposure to high concentrations can cause irritation to the skin, eyes, and respiratory system. Researchers and workers should wear appropriate personal protective equipment and follow safety protocols when working with this compound.

Regulatory Aspects

The production, import, and export of 2-Anilinoethanol are subject to regulatory controls. These regulations are in place to ensure the safe handling and use of the compound. Researchers and manufacturers must comply with the relevant laws and regulations to prevent any adverse effects on human health and the environment.

Conclusion

2-Anilinoethanol (CAS 122-98-5) is a versatile compound with significant applications in organic synthesis, pharmaceuticals, and agrochemicals. Its unique chemical properties and synthesis methods make it a valuable tool in research and development. However, its potential toxicity and regulatory status necessitate careful handling and compliance with safety protocols. This article has provided a comprehensive overview of the essential facts about 2-Anilinoethanol, offering valuable insights for researchers in various scientific fields.

Keywords

2-Anilinoethanol, CAS 122-98-5, chemical properties, synthesis methods, organic synthesis, pharmaceuticals, agrochemicals, safety considerations, regulatory aspects.