Discover the Power of 3-Trifluoromethylphenol CAS 98-17-9： A Must-Read for Researchers

Abstract

This article provides an in-depth exploration of the significance of 3-Trifluoromethylphenol, a chemical compound with the CAS number 98-17-9. Known for its unique properties and potential applications, this compound has garnered considerable interest among researchers. The article delves into the various aspects of 3-Trifluoromethylphenol, including its chemical structure, synthesis methods, properties, applications, and safety considerations. It aims to serve as a comprehensive guide for researchers looking to understand and utilize this compound in their work.

Introduction to 3-Trifluoromethylphenol

3-Trifluoromethylphenol, also known as 3-trifluoromethylphenol, is a chemical compound characterized by a phenol ring substituted with a trifluoromethyl group at the third position. This substitution imparts unique physical and chemical properties to the compound, making it a subject of interest in various scientific fields. The compound is widely used in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.

Chemical Structure and Synthesis

The chemical structure of 3-Trifluoromethylphenol consists of a benzene ring with a hydroxyl group (-OH) attached to the third carbon atom and a trifluoromethyl group (-CF3) attached to the fourth carbon atom. The synthesis of 3-Trifluoromethylphenol can be achieved through various methods, including the reaction of 4-chloroaniline with triflic anhydride, followed by hydrolysis. Another common method involves the reaction of 4-chloroaniline with sodium nitrite in the presence of hydrochloric acid, which leads to the formation of the desired compound.

Properties of 3-Trifluoromethylphenol

3-Trifluoromethylphenol exhibits several distinct properties that make it valuable in various applications. It has a melting point of approximately 53-55°C and a boiling point of around 224-226°C. The compound is soluble in organic solvents such as acetone, chloroform, and benzene but is sparingly soluble in water. Its unique physical properties, combined with its chemical reactivity, make it a versatile starting material for the synthesis of other compounds.

Applications of 3-Trifluoromethylphenol

The applications of 3-Trifluoromethylphenol are diverse and span across several industries. In the pharmaceutical industry, it serves as a key intermediate in the synthesis of various drugs, including anti-inflammatory agents and analgesics. In agrochemicals, it is used in the production of herbicides and insecticides. Additionally, 3-Trifluoromethylphenol finds applications in the synthesis of dyes, polymers, and other specialty chemicals.

Safety Considerations

As with any chemical compound, safety considerations are paramount when handling 3-Trifluoromethylphenol. The compound is toxic if ingested, inhaled, or absorbed through the skin. It is also a skin and eye irritant. Proper handling and storage procedures, as well as the use of appropriate personal protective equipment, are essential to minimize the risk of exposure. Researchers and industrial users should adhere to the guidelines provided by safety data sheets (SDS) and local regulations.

Conclusion

In conclusion, 3-Trifluoromethylphenol, with its CAS number 98-17-9, is a chemical compound that has gained significant attention due to its unique properties and potential applications. Its chemical structure, synthesis methods, properties, and applications make it a valuable resource for researchers in various scientific fields. While safety considerations must be taken into account, the compound's versatility and potential for innovation make it a must-read for any researcher looking to explore new frontiers in chemistry and its applications.

Keywords

3-Trifluoromethylphenol, CAS 98-17-9, chemical structure, synthesis, properties, applications, safety considerations, pharmaceuticals, agrochemicals, specialty chemicals.