Guaifenesin CAS 93-14-1： Everything You Need to Know About This Compound

Abstract

This article provides an in-depth overview of Guaifenesin CAS 93-14-1, a commonly used compound with expectorant properties. It explores its chemical structure, therapeutic uses, potential side effects, manufacturing process, regulatory status, and its role in various industries. By delving into these aspects, the article aims to offer a comprehensive understanding of this compound and its significance.

Introduction to Guaifenesin CAS 93-14-1

Guaifenesin, with the CAS number 93-14-1, is a widely recognized compound known for its expectorant properties. It is primarily used in the treatment of respiratory conditions that cause cough and mucus accumulation. This article will explore the various facets of guaifenesin, from its chemical structure to its applications in different industries.

Chemical Structure and Properties

Guaifenesin is a white, crystalline solid that belongs to the guaifenesin class of compounds. It has a molecular formula of C₁₀H₁₆O₃ and a molecular weight of 196.23 g/mol. The compound has a melting point of 140-142°C and is soluble in water, alcohol, and chloroform. Its chemical structure consists of a guaifenesin ring with a hydroxyl group attached to the 4-position and a carboxyl group attached to the 5-position.

The expectorant properties of guaifenesin are attributed to its ability to reduce the viscosity of mucus, making it easier to cough up. This property is particularly beneficial in respiratory conditions such as bronchitis, asthma, and colds.

Therapeutic Uses

Guaifenesin is primarily used as an expectorant in the treatment of respiratory conditions. It is commonly found in cough syrups, lozenges, and tablets. The compound helps to thin mucus, which can alleviate symptoms such as coughing, chest congestion, and difficulty breathing.

In addition to its expectorant properties, guaifenesin has also been studied for its potential use in other therapeutic applications. For example, it has been investigated for its anti-inflammatory effects and its potential role in the treatment of chronic obstructive pulmonary disease (COPD).

Potential Side Effects

While guaifenesin is generally considered safe for most people, it can cause side effects in some individuals. Common side effects include nausea, stomach pain, and diarrhea. In rare cases, allergic reactions to guaifenesin may occur, which can manifest as hives, itching, or difficulty breathing.

It is important for patients to follow the recommended dosage and consult with a healthcare professional before taking guaifenesin, especially if they have pre-existing medical conditions or are taking other medications.

Manufacturing Process

The manufacturing of guaifenesin involves a multi-step process that includes the synthesis of the guaifenesin ring and the subsequent attachment of the hydroxyl and carboxyl groups. The synthesis typically starts with the reaction of a guaifenesin precursor with a suitable reagent to form the guaifenesin ring. Subsequent steps involve the selective attachment of the hydroxyl and carboxyl groups to the ring.

The manufacturing process requires careful control of reaction conditions to ensure the purity and quality of the final product. Quality control measures are in place to detect impurities and ensure that the guaifenesin meets the required specifications.

Regulatory Status

Guaifenesin is regulated by various health authorities around the world. In the United States, it is classified as an over-the-counter (OTC) drug, meaning it can be purchased without a prescription. However, it is still subject to regulatory oversight to ensure its safety and efficacy.

In the European Union, guaifenesin is also classified as an OTC drug and is regulated by the European Medicines Agency (EMA). Similar regulations apply in other regions, ensuring that guaifenesin is used safely and responsibly.

Role in Various Industries

Guaifenesin has applications beyond its therapeutic uses. It is used in the pharmaceutical industry as an active ingredient in cough and cold remedies. Additionally, it is used in the food industry as a flavoring agent and in the cosmetic industry as a skin conditioning agent.

The versatility of guaifenesin makes it a valuable compound in various industries, contributing to its widespread use and demand.

Conclusion

Guaifenesin CAS 93-14-1 is a compound with significant therapeutic value, primarily known for its expectorant properties. This article has provided a comprehensive overview of guaifenesin, covering its chemical structure, therapeutic uses, potential side effects, manufacturing process, regulatory status, and its role in various industries. Understanding these aspects is crucial for healthcare professionals, patients, and those involved in the production and regulation of guaifenesin.

Keywords: Guaifenesin, CAS 93-14-1, expectorant, therapeutic uses, side effects, manufacturing, regulatory status, pharmaceutical industry.