The product we are introducing here is High Quality 4-nitrophenyl chloroformate with the CAS number 7693 - 46 - 1. 4 - nitrophenyl chloroformate is an important organic compound in the chemical industry. Its molecular formula is C₇H₄ClNO₄, and its molecular weight is approximately 201.56 g/mol. This product is usually in solid form at room temperature. It has a characteristic appearance, often presenting as a white or light - yellow crystalline powder. The quality of our product is strictly controlled to ensure high purity, which is reflected in its excellent performance in various chemical reactions.
Regarding its physical and chemical properties, it has a certain solubility in some organic solvents such as dichloromethane, chloroform, and acetonitrile. However, it is unstable in water and will react with water, so it should be stored in a dry and cool environment to prevent moisture. The melting point of 4 - nitrophenyl chloroformate is around 75 - 77 °C.
4 - nitrophenyl chloroformate has a wide range of applications in the chemical and pharmaceutical industries. In the field of organic synthesis, it is a very useful reagent. It can be used as an acylating agent to introduce a carbonyl group into organic molecules. For example, it can react with amines to form carbamates. This reaction is very important in the synthesis of various drugs, pesticides, and polymers.
In the pharmaceutical industry, it is often used in the synthesis of new drug candidates. Many drugs contain carbamate or carbonate functional groups, and 4 - nitrophenyl chloroformate is an ideal starting material for introducing these groups. It can also be used in the modification of biomolecules, such as proteins and peptides. By reacting with the amino groups on biomolecules, it can change the properties and functions of biomolecules, which is very important for the development of new drugs and biological products.
When using 4 - nitrophenyl chloroformate, some safety precautions should be taken. First of all, it should be operated in a well - ventilated fume hood because it may release irritating gases during the reaction. Wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. Before use, make sure the reaction vessel is dry and clean to avoid unnecessary side reactions.
Typically, in an organic synthesis reaction, a certain amount of 4 - nitrophenyl chloroformate is dissolved in an appropriate organic solvent. Then, the reactant (such as an amine) is slowly added drop - wise under stirring. The reaction temperature and time should be carefully controlled according to the specific reaction requirements. After the reaction is completed, the product can be purified by methods such as extraction, recrystallization, or column chromatography.
Case 1: In a pharmaceutical research project, a research team was trying to synthesize a new drug candidate with a carbamate functional group. They used 4 - nitrophenyl chloroformate as the acylating agent. First, they dissolved 5 grams of 4 - nitrophenyl chloroformate in 50 mL of dichloromethane in a round - bottom flask. Then, they slowly added 3 grams of a specific amine dissolved in 20 mL of dichloromethane drop - wise over 30 minutes while stirring at 0 °C. After the addition was completed, the reaction mixture was stirred at room temperature for another 2 hours. Through subsequent purification steps, they successfully obtained the target product with a yield of 70%. This new drug candidate showed good biological activity in preliminary tests.
Case 2: In a polymer synthesis experiment, 4 - nitrophenyl chloroformate was used to introduce carbonate groups into a polymer chain. A polymer with hydroxyl groups was dissolved in acetonitrile, and then an appropriate amount of 4 - nitrophenyl chloroformate was added. After a series of reactions and treatments, a new polymer with improved mechanical properties was obtained, which has potential applications in the field of materials science.
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