3-Amino-1-adamantanol CAS 702-82-9： What You Need to Know About This Molecule

Abstract

This article provides an in-depth overview of 3-Amino-1-adamantanol CAS 702-82-9, a molecule that has garnered attention in various scientific fields. The article delves into its chemical structure, synthesis methods, biological activities, potential applications, safety considerations, and environmental impact. By exploring these aspects, readers will gain a comprehensive understanding of this compound and its significance in modern chemistry and related disciplines.

Introduction to 3-Amino-1-adamantanol CAS 702-82-9

3-Amino-1-adamantanol, with the CAS number 702-82-9, is a unique organic compound that belongs to the adamantane family. It is characterized by a cyclic structure consisting of a fused ring system, which gives it distinct physical and chemical properties. This molecule has been the subject of extensive research due to its potential applications in pharmaceuticals, agrochemicals, and materials science.

Chemical Structure and Properties

The chemical structure of 3-Amino-1-adamantanol features an adamantane core with an amino group (-NH2) attached to the third carbon atom. This functional group introduces polar characteristics to the molecule, which can influence its solubility and reactivity. The cyclic structure of adamantane contributes to the molecule's stability and resistance to degradation, making it suitable for various applications.

The physical properties of 3-Amino-1-adamantanol include a melting point of approximately 123°C and a boiling point of around 312°C. It is sparingly soluble in water but more soluble in organic solvents such as ethanol and acetone. These properties make it a versatile compound for synthesis and applications in different fields.

Synthesis Methods

The synthesis of 3-Amino-1-adamantanol can be achieved through various methods, including the reduction of 3-nitroadamantane, the amination of 1-adamantanol, and the reaction of 1-adamantanol with ammonia. Each method has its advantages and limitations, and the choice of synthesis route depends on the desired purity, yield, and cost-effectiveness.

The reduction of 3-nitroadamantane is a common method for synthesizing 3-Amino-1-adamantanol. This process involves the use of reducing agents such as sodium borohydride or lithium aluminum hydride, which convert the nitro group (-NO2) into an amino group (-NH2). The amination of 1-adamantanol is another approach, where ammonia or an amine derivative is used to introduce the amino group. The reaction of 1-adamantanol with ammonia is a straightforward method that yields the desired product in a single step.

Biological Activities

3-Amino-1-adamantanol has shown potential biological activities, including anti-inflammatory, antioxidant, and antimicrobial properties. These activities have sparked interest in its application as a therapeutic agent for various diseases. Research has indicated that the molecule can modulate the immune response, reduce oxidative stress, and inhibit the growth of certain pathogens.

In vitro studies have demonstrated that 3-Amino-1-adamantanol can inhibit the activity of inflammatory enzymes such as cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). This suggests its potential as an anti-inflammatory agent for the treatment of conditions like arthritis and inflammatory bowel disease. Additionally, the molecule has been found to possess antioxidant properties, which may contribute to its protective effects against oxidative stress and cellular damage.

Potential Applications

The unique properties of 3-Amino-1-adamantanol make it a promising candidate for various applications. In the pharmaceutical industry, it has the potential to be developed into new drugs for the treatment of inflammatory diseases, oxidative stress-related disorders, and infectious diseases. Its antimicrobial properties may also make it useful in the development of new antibiotics.

In agrochemicals, 3-Amino-1-adamantanol could be used as a herbicide or insecticide due to its potential to disrupt the growth and development of plants and insects. Furthermore, its cyclic structure and stability make it a potential candidate for the development of novel materials, such as polymers and coatings, with improved mechanical and thermal properties.

Safety Considerations

As with any chemical compound, the safety of 3-Amino-1-adamantanol is a crucial consideration. Toxicological studies have been conducted to assess its potential risks to human health and the environment. The acute toxicity of the molecule has been found to be low, with no significant adverse effects observed at high doses. However, long-term exposure and chronic toxicity studies are still needed to fully understand the potential risks associated with the compound.

In terms of environmental impact, 3-Amino-1-adamantanol is considered to be biodegradable, which means it can be broken down by natural processes. However, the rate of biodegradation and the potential for bioaccumulation in the food chain are factors that need to be monitored and controlled to minimize environmental risks.

Environmental Impact

The environmental impact of 3-Amino-1-adamantanol is an important aspect to consider, especially in its potential applications in agrochemicals. As mentioned earlier, the molecule is considered biodegradable, which is a positive attribute. However, the rate of biodegradation can vary depending on the environmental conditions, such as temperature, pH, and the presence of other substances.

Additionally, the potential for 3-Amino-1-adamantanol to bioaccumulate in organisms needs to be assessed. Bioaccumulation refers to the process by which a substance accumulates in the tissues of organisms over time, leading to increased concentrations in higher trophic levels. This can have adverse effects on the health of aquatic ecosystems and the organisms that inhabit them.

Conclusion

In conclusion, 3-Amino-1-adamantanol CAS 702-82-9 is a fascinating molecule with a range of potential applications in pharmaceuticals, agrochemicals, and materials science. Its unique chemical structure, synthesis methods, biological activities, and safety considerations make it a subject of significant interest in the scientific community. As research continues to unfold, a better understanding of this compound will undoubtedly lead to new discoveries and advancements in various fields.

Keywords: 3-Amino-1-adamantanol, CAS 702-82-9, adamantane, synthesis, biological activities, potential applications, safety, environmental impact