CAS 19692-45-6： 4-Tert-Butylbenzyl Chloride - Everything You Need to Know

Abstract

This article provides an in-depth overview of CAS 19692-45-6, also known as 4-Tert-Butylbenzyl Chloride. It covers the chemical properties, synthesis methods, applications, safety considerations, and regulatory information associated with this compound. By exploring these aspects, the article aims to offer a comprehensive understanding of 4-Tert-Butylbenzyl Chloride, its uses, and its significance in various industries.

Introduction to CAS 19692-45-6: 4-Tert-Butylbenzyl Chloride

CAS 19692-45-6, or 4-Tert-Butylbenzyl Chloride, is an organic compound with the molecular formula C10H14Cl. It is a colorless liquid with a sweet, aromatic odor. This compound is widely used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. In this article, we will delve into the various aspects of 4-Tert-Butylbenzyl Chloride, including its chemical properties, synthesis, applications, safety, and regulatory aspects.

Chemical Properties of 4-Tert-Butylbenzyl Chloride

4-Tert-Butylbenzyl Chloride is a chlorinated derivative of benzene, with a tert-butyl group attached to the benzyl position. The molecular structure of this compound consists of a benzene ring with a chlorine atom attached to one of the carbon atoms, and a tert-butyl group attached to the adjacent carbon atom. The chemical formula for 4-Tert-Butylbenzyl Chloride is C10H14Cl, and its molecular weight is 154.60 g/mol. The compound has a melting point of -35.5°C and a boiling point of 254°C. It is soluble in organic solvents such as ether, chloroform, and acetone but is not soluble in water.

Synthesis of 4-Tert-Butylbenzyl Chloride

The synthesis of 4-Tert-Butylbenzyl Chloride typically involves the reaction of 4-tert-butylbenzyl alcohol with thionyl chloride (SOCl2) in the presence of a catalytic amount of pyridine. This reaction is known as the Swern oxidation and results in the conversion of the alcohol into the corresponding chloride. The overall reaction can be represented as follows:

\[ \text{4-tert-Butylbenzyl alcohol} + \text{SOCl}_2 \xrightarrow{\text{pyridine}} \text{4-tert-Butylbenzyl chloride} + \text{HCl} + \text{SO}_2 \]

The reaction conditions are usually carried out at room temperature, and the yield of the product is typically high.

Applications of 4-Tert-Butylbenzyl Chloride

4-Tert-Butylbenzyl Chloride finds applications in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and fine chemicals. Some of the key applications include:

1. **Pharmaceuticals**: It is used as an intermediate in the synthesis of certain drugs, such as antiviral agents and anti-inflammatory compounds.
2. **Agrochemicals**: It serves as a precursor in the production of herbicides and insecticides.
3. **Fine Chemicals**: It is utilized in the synthesis of dyes, pigments, and other specialty chemicals.

The versatility of 4-Tert-Butylbenzyl Chloride in organic synthesis makes it a valuable compound in the chemical industry.

Safety Considerations for 4-Tert-Butylbenzyl Chloride

Handling 4-Tert-Butylbenzyl Chloride requires caution due to its potential health hazards. The compound is toxic if inhaled, ingested, or absorbed through the skin. It can cause irritation to the eyes, skin, and respiratory system. Therefore, appropriate safety measures, such as wearing protective gloves, goggles, and a lab coat, should be taken when working with this chemical. Adequate ventilation is also essential to prevent the accumulation of vapors.

Regulatory Information for 4-Tert-Butylbenzyl Chloride

The production, import, and export of 4-Tert-Butylbenzyl Chloride are subject to various regulations and guidelines. These regulations are in place to ensure the safe handling and use of the compound. The European Chemicals Agency (ECHA) and the United States Environmental Protection Agency (EPA) are among the regulatory bodies that oversee the use of this chemical. Compliance with these regulations is crucial for businesses involved in the manufacturing and distribution of 4-Tert-Butylbenzyl Chloride.

Conclusion

CAS 19692-45-6, or 4-Tert-Butylbenzyl Chloride, is a versatile organic compound with significant applications in the chemical industry. Its synthesis, chemical properties, and safety considerations are crucial aspects to understand for anyone involved in its production or use. By providing a comprehensive overview of 4-Tert-Butylbenzyl Chloride, this article aims to serve as a valuable resource for professionals in the field.

Keywords: CAS 19692-45-6, 4-Tert-Butylbenzyl Chloride, chemical properties, synthesis, applications, safety, regulatory information