Caryophyllene Oxide, with the CAS number 1139 - 30 - 6, is a natural sesquiterpene oxide. It is commonly found in various essential oils, such as clove oil, cinnamon oil, and cannabis oil. The molecular formula of Caryophyllene Oxide is C15H24O, and its molecular weight is approximately 220.35 g/mol. Physically, it is a colorless to pale - yellow liquid with a unique, spicy - woody odor. The boiling point of Caryophyllene Oxide ranges around 275 - 280 °C, and it has a density of about 0.965 g/cm³ at 20 °C. It is slightly soluble in water but highly soluble in organic solvents like ethanol, ether, and chloroform.
In the fragrance industry, Caryophyllene Oxide is highly valued for its warm, spicy, and woody aroma. It is often used as a base note in perfumes, colognes, and scented candles, adding depth and complexity to the overall fragrance profile. It can also be used in the formulation of home care products, such as air fresheners and laundry detergents, to provide a long - lasting, pleasant scent.
In the field of medicine, Caryophyllene Oxide has shown potential therapeutic properties. It has anti - inflammatory, analgesic, and antimicrobial effects. Research suggests that it may be beneficial in treating inflammations, pain management, and preventing microbial infections. Additionally, it has been studied for its potential role in neurodegenerative diseases due to its neuroprotective properties.
In the agricultural sector, Caryophyllene Oxide can be used as a natural pest repellent. Its unique chemical structure makes it unattractive to many common agricultural pests, reducing the need for synthetic pesticides.
**Fragrance Applications**: When using Caryophyllene Oxide in perfume formulation, it should be used in moderation. Start by adding a small amount (about 1 - 5%) to the perfume base and gradually adjust according to the desired intensity of the fragrance. It can be mixed with other essential oils and fragrance compounds using standard perfume - making techniques. For scented candles, add it to the melted wax at a temperature below its boiling point, usually around 60 - 70 °C, and stir well to ensure even distribution.
**Medical Applications**: In medical research or herbal medicine, Caryophyllene Oxide can be used in the form of an essential oil. It can be diluted with a carrier oil (such as coconut oil or jojoba oil) at a ratio of 1 - 5% for topical application to relieve pain and inflammation. For internal use, it should only be under the guidance of a qualified healthcare professional, as the dosage needs to be carefully controlled.
**Agricultural Applications**: As a pest repellent, it can be diluted in water and sprayed on plants. A typical dilution ratio is about 0.1 - 1% of Caryophyllene Oxide in water. Make sure to cover the entire plant surface evenly for effective pest control.
**Fragrance Industry Case**: A well - known perfume brand was looking to create a new men's cologne with a long - lasting, sophisticated scent. They incorporated Caryophyllene Oxide as a base note. By carefully blending it with other essential oils like bergamot, lavender, and sandalwood, they created a unique fragrance that received positive feedback from consumers. The warm, spicy aroma of Caryophyllene Oxide added a touch of masculinity and depth to the cologne, making it stand out in the market.
**Medical Case**: In a clinical trial for pain management, patients with mild to moderate arthritis pain were treated with a topical cream containing 3% Caryophyllene Oxide. After a few weeks of use, many patients reported a significant reduction in pain and inflammation. The anti - inflammatory and analgesic properties of Caryophyllene Oxide were found to be effective in relieving the symptoms of arthritis.
**Agricultural Case**: A small - scale organic farm was facing a problem with aphid infestations on their tomato plants. They decided to use a spray made with 0
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