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High Quality N-(p-Tolylsulfonylmethyl)formamide CAS 36635-56-0: Comprehensive User Guide

Table of Contents

1. Introduction

N-(p-Tolylsulfonylmethyl)formamide (CAS 36635-56-0) is a high-purity chemical intermediate widely used in organic synthesis. Known for its stability and reactivity, it is a critical component in pharmaceutical and fine chemical manufacturing.

2. Product Specifications

  • CAS Number: 36635-56-0
  • Molecular Formula: C9H11NO3S
  • Molecular Weight: 213.25 g/mol
  • Appearance: White to off-white crystalline powder
  • Purity: ≥98% (HPLC)
  • Storage: Store at 2-8°C in a dry, dark environment

3. Key Applications

This compound is primarily utilized as:

  • A sulfonating agent in Mitsunobu reactions.
  • An intermediate in synthesizing protease inhibitors and antiviral drugs.
  • A reagent for introducing sulfonyl groups in peptide modifications.

4. Usage Guidelines

Safety Precautions

  • Wear PPE (gloves, goggles, lab coat).
  • Avoid inhalation or direct contact with skin.

Recommended Procedure

  1. Dissolve in anhydrous DMF or THF under inert atmosphere.
  2. Use at 0.5-2.0 molar equivalents depending on reaction scale.
  3. Maintain temperature between 0-25°C during addition.

5. Case Studies

Case 1: Synthesis of Antiviral Drug Intermediate

In a 2023 study, 5g of N-(p-Tolylsulfonylmethyl)formamide was used to sulfonylate a nucleoside analog precursor in DMF at 20°C, achieving 92% yield with >99% purity after crystallization.

Case 2: Peptide Crosslinking Application

Researchers successfully employed 0.8 equivalents of this reagent in a solid-phase peptide synthesis to introduce sulfonamide linkages, demonstrating enhanced stability under physiological conditions.

6. Contact Information

For technical inquiries or bulk orders:

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

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By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

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Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

User’evaluation of us

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