1-Bromo-3-ethynyl-benzene (CAS 766-81-4) is a specialized aromatic compound with the molecular formula C8H5Br. Key specifications include:
This compound serves as a versatile intermediate in:
Safety Precautions:
Handling:
Case 1: Synthesis of Anticancer Compound
Used in palladium-catalyzed Sonogashira coupling with 4-iodobenzamide (1:1.2 molar ratio) in THF/TEA (3:1) at 60°C for 12 hours, achieving 82% yield of target acetylene derivative.
Case 2: OLED Material Development
Employed in Suzuki-Miyaura reaction with phenylboronic acid (1:1.05 ratio) using Pd(PPh3)4 catalyst in dioxane/H2O (4:1) at 90°C, producing luminescent biphenyl derivatives for display technologies.
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