Our product is high - quality Methyllithium with the CAS number 917 - 54 - 4. Methyllithium is an organolithium compound with the chemical formula CH₃Li. It is a colorless solid under normal conditions but often appears in solution form, usually dissolved in solvents like diethyl ether or tetrahydrofuran (THF).
The molecular weight of Methyllithium is approximately 21.98 g/mol. It has a high reactivity due to the highly polar carbon - lithium bond. The bond polarity makes it a strong nucleophile and a strong base, which are the key chemical properties that determine its wide range of applications in organic synthesis.
Methyllithium is a versatile reagent in organic chemistry. One of its primary uses is in the field of organic synthesis. It can be used for the formation of carbon - carbon bonds, which is a fundamental reaction in the construction of complex organic molecules. For example, it can react with carbonyl compounds such as aldehydes and ketones to form alcohols. In the reaction with esters, it can lead to the formation of tertiary alcohols.
Another important application is in the field of polymer chemistry. Methyllithium can be used as an initiator for anionic polymerization reactions. It can initiate the polymerization of monomers like styrene and butadiene, resulting in the production of polymers with specific properties and structures.
When handling Methyllithium, strict safety precautions must be followed. Since it is highly reactive and can react violently with water and air, all operations should be carried out under an inert atmosphere, typically nitrogen or argon.
Before use, make sure the reaction vessel is thoroughly dried to remove any traces of moisture. When adding Methyllithium to a reaction mixture, it should be added slowly and carefully, especially when reacting with highly reactive substrates. The reaction temperature should also be carefully controlled, as many reactions involving Methyllithium are exothermic.
After the reaction is completed, proper quenching procedures should be followed. Quenching agents such as ethanol or water - saturated solvents can be used, but this should be done slowly and with caution to avoid any violent reactions.
Case 1: Synthesis of a Tertiary Alcohol
In a research project aimed at synthesizing a complex natural product, Methyllithium was used to react with an ester. First, a dry three - necked flask was filled with nitrogen. The ester was dissolved in dry THF and cooled to - 78°C. Then, Methyllithium solution in diethyl ether was slowly added drop - wise to the reaction mixture. After the addition was completed, the reaction mixture was slowly warmed to room temperature and stirred for several hours. After work - up, the desired tertiary alcohol was obtained in a good yield. This demonstrated the effectiveness of Methyllithium in forming carbon - carbon bonds and synthesizing complex organic molecules.
Case 2: Anionic Polymerization of Styrene
In a polymer synthesis laboratory, Methyllithium was used as an initiator for the anionic polymerization of styrene. The reaction was carried out in a dry Schlenk flask under an argon atmosphere. A solution of Methyllithium in THF was added to a solution of styrene in THF. The reaction was allowed to proceed at room temperature for a certain period of time. The resulting polystyrene had a narrow molecular weight distribution, indicating the well - controlled nature of the anionic polymerization initiated by Methyllithium.
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