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4-Hydrazinobenzene-1-sulfonamide Hydrochloride (CAS 17852-52-7) User Guide

Table of Contents

1. Product Information

Chemical Name: 4-Hydrazinobenzene-1-sulfonamide Hydrochloride

CAS Number: 17852-52-7

Molecular Formula: C6H9ClN4O2S

Molecular Weight: 236.68 g/mol

Appearance: White to off-white crystalline powder

Purity: ≥98% (HPLC)

Storage: Keep in a cool, dry place at 2-8°C

Supply: Available in bulk quantities with competitive pricing.

2. Product Usage

4-Hydrazinobenzene-1-sulfonamide Hydrochloride (CAS 17852-52-7) is a key intermediate in pharmaceutical and organic synthesis. Its primary applications include:

  • Synthesis of sulfonamide-based antibiotics and antimicrobial agents.
  • Preparation of hydrazine derivatives for agrochemical research.
  • Use as a reagent in coupling reactions for functionalized aromatic compounds.
  • Intermediate in the production of dyes and pigments.

3. How to Use

Safety Precautions

  • Wear PPE: gloves, lab coat, and safety goggles.
  • Avoid inhalation or direct skin contact.
  • Use in a well-ventilated area or fume hood.

Handling Instructions

  • Weigh accurately using a calibrated balance.
  • Dissolve in polar solvents (e.g., DMSO, ethanol) under controlled conditions.
  • Store unused material in airtight containers away from moisture.

4. Detailed Use Cases

Case Study 1: Synthesis of Sulfamethoxazole

4-Hydrazinobenzene-1-sulfonamide HCl is reacted with 5-methylisoxazole-3-carbonyl chloride in anhydrous DMF at 40°C for 6 hours to yield sulfamethoxazole, a widely used antibiotic. Yield: 85-90%.

Case Study 2: Coupling Agent for Bioconjugation

In bioconjugate chemistry, this compound facilitates the linkage of proteins to fluorescent probes. A typical protocol involves:

  1. Activate the sulfonamide group with EDC/NHS.
  2. Mix with target protein (1:5 molar ratio) in PBS buffer (pH 7.4).
  3. Purify via dialysis and lyophilize for storage.

5. Contact Information

For technical inquiries or bulk orders:

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About the company

Vivalr, a paragon of innovation in the chemical sector, fuses cutting - edge R & D with unwavering commitment to quality. Our product spectrum, from industrial stalwarts to fine - tuned chemicals, is a testament to our versatility.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

By Air, fast but expensive.

By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

Environmental Protection Science and Technology Park, Zhengfeng Road, High-tech Zone, Jinan City, Shandong Province

Whether to provide samples?

Free samples can be provided, and customers only need to pay the corresponding shipping costs

Delivery time

There are stock in the warehouse, and some products need to be customized for production within 3 working days, depending on the workshop situation and production schedule

What payment methods and currencies are accepted here?

We accept payment methods such as TT, Western Union, and letter of credit, etc. Meanwhile, we support currencies like US dollars, euros, RMB, and Bitcoin, etc.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

User’evaluation of us

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" In years of sourcing from China, first found working with Sincere Chemical great. They help in production, delivery and tech, saving time. When first asking Zhai for optical brightener quote, got detailed one with prices, trade details, company info, R&D and production capacity, packaging and raw material control."

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Marcus Long

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Emma Kung

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Lisa Phoenix

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