Factory Supply Cremophor EL with CAS number 61791 - 12 - 6 is a non - ionic solubilizer and emulsifier. It is a yellowish to amber, oily liquid with a faint characteristic odor. Chemically, it is a polyethoxylated castor oil, typically with an average of 35 moles of ethylene oxide per mole of castor oil.
Key parameters of Cremophor EL include:
Cremophor EL has a wide range of applications in various industries:
Pharmaceutical Industry: It is commonly used as a solubilizer and emulsifier in parenteral formulations. It can enhance the solubility of poorly water - soluble drugs, allowing for the development of injectable solutions. For example, it has been used in the formulation of some anticancer drugs to improve their bioavailability.
Cosmetics and Personal Care: In cosmetics, Cremophor EL is used as an emulsifier in creams, lotions, and hair care products. It helps to blend oil and water phases, creating stable and smooth formulations. It can also act as a solubilizer for fragrances and other lipophilic ingredients.
Food Industry: Although its use in food is more restricted, in some cases, it can be used as an emulsifying agent in certain food products where permitted by relevant regulations.
Dosage: The dosage of Cremophor EL depends on the specific application. In pharmaceutical formulations, the concentration can range from a few percent to higher levels, depending on the solubility requirements of the drug. In cosmetics, typical concentrations are usually in the range of 1 - 5%.
Preparation: When using Cremophor EL, it is important to ensure proper mixing. In the case of formulating emulsions, it is usually added during the emulsification process. First, the oil - phase ingredients are mixed, and then Cremophor EL is added and thoroughly dispersed. The water - phase is then slowly added under continuous stirring to form a stable emulsion.
Storage: Cremophor EL should be stored in a cool, dry place, away from direct sunlight and heat sources. It should be kept in a well - sealed container to prevent oxidation and contamination.
Pharmaceutical Case: A pharmaceutical company was developing an injectable formulation for a new anticancer drug. The drug had extremely poor water solubility, which made it difficult to formulate into an injectable solution. By using Cremophor EL as a solubilizer, the company was able to dissolve the drug at an appropriate concentration. During pre - clinical and clinical trials, the formulation showed improved bioavailability and efficacy compared to other non - solubilized formulations. The use of Cremophor EL also helped to maintain the stability of the drug in the solution over an extended period.
Cosmetics Case: A cosmetics brand was launching a new moisturizing lotion. They wanted a stable and smooth emulsion that could effectively deliver the active ingredients. By incorporating 2% Cremophor EL into the formulation, they were able to achieve a well - blended oil - in - water emulsion. The lotion had a pleasant texture and good spreadability. Consumer feedback indicated high satisfaction with the product's moisturizing effect and overall quality.
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