Product Name: Factory Supply 4-Hydroxybenzoic acid CAS 99-96-7 With Best Price
CAS Number: 99 - 96 - 7
4-Hydroxybenzoic acid is a phenolic carboxylic acid. It exists as a white crystalline powder. Its molecular formula is C₇H₆O₃, and the molecular weight is 138.12 g/mol. The melting point of 4-Hydroxybenzoic acid is around 213 - 217 °C, and it is sparingly soluble in cold water but more soluble in hot water, ethanol, and ether.
4-Hydroxybenzoic acid has a wide range of applications. In the field of cosmetics and personal care products, it is a crucial raw material for synthesizing parabens, which are widely used as preservatives. Parabens can effectively inhibit the growth of bacteria, molds, and yeasts, thus extending the shelf - life of products such as lotions, creams, shampoos, and makeup products.
In the pharmaceutical industry, 4-Hydroxybenzoic acid can be used in the synthesis of some drugs. It can also be used as an intermediate in the production of various pharmaceutical compounds due to its chemical reactivity.
In the food industry, although not directly used as a food additive in most regions, its derivatives may be used as food preservatives under strict regulations to ensure food safety during storage and transportation.
When using 4-Hydroxybenzoic acid in the synthesis of parabens for cosmetics, first, it needs to be properly dissolved. Usually, it can be dissolved in an appropriate amount of ethanol or other solvents under heating and stirring conditions. The reaction with alcohols to form esters is carried out under the catalysis of an acid catalyst, such as sulfuric acid. The reaction temperature and time should be strictly controlled according to the reaction conditions to ensure the high yield of the product.
In the pharmaceutical synthesis process, the specific reaction steps and conditions depend on the target compound. It is necessary to follow the established synthetic routes and use appropriate reaction solvents, catalysts, and reaction temperatures. Appropriate safety measures should be taken during the operation, such as wearing protective equipment and working in a well - ventilated environment.
Case Study 1: Cosmetics Manufacturer
A cosmetics manufacturer wanted to develop a new line of anti - aging creams. They used 4-Hydroxybenzoic acid to synthesize methyl paraben as a preservative. First, they dissolved 4-Hydroxybenzoic acid in ethanol at 60 °C with continuous stirring. Then, they added methanol and a small amount of sulfuric acid as a catalyst. The reaction was carried out at 80 °C for 3 hours. After purification, the obtained methyl paraben was added to the cream formula at a concentration of 0.2%. The cream was tested for microbiological stability, and it passed the required tests, ensuring a long shelf - life of the product.
Caso práctico 2: Empresa farmacéutica
A pharmaceutical company aimed to synthesize a new anti - inflammatory drug. 4-Hydroxybenzoic acid was used as an intermediate. They reacted it with a specific amine compound in an organic solvent under basic conditions. The reaction temperature was maintained at 100 °C for 5 hours. After a series of purification steps, the target compound was obtained with a high purity. The new drug showed good anti - inflammatory effects in pre - clinical trials.
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