The product we are introducing here is Factory Supply sodium cholate with the cas number 361 - 09 - 1 and is available at a low price. Sodium cholate is an important bile salt, which is a sodium salt of cholic acid. Its molecular formula is C₂₄H₃₉NaO₅, and the molecular weight is approximately 430.55 g/mol. It appears as a white to off - white powder. It is soluble in water and ethanol, and the melting point is around 300 °C. This product is usually supplied in a well - sealed container to ensure its quality and stability.
Sodium cholate has a wide range of applications in various fields. In the pharmaceutical industry, it is often used as an emulsifying agent. It can help drugs be better dissolved and absorbed in the body, especially for some fat - soluble drugs. By forming micelles with drugs, it increases the solubility and bioavailability of drugs, thereby enhancing the therapeutic effect. In biochemical research, sodium cholate is used as a detergent in membrane protein research. It can solubilize membrane proteins while maintaining their native structure and activity, which is crucial for studying the function and structure of membrane proteins. Additionally, in the food industry, it can be used as an emulsifier and stabilizer in some dairy products and beverages to improve the stability and texture of products.
When using sodium cholate, it is important to follow the correct procedures. In a laboratory setting, if you are using it for membrane protein solubilization, first, prepare a buffer solution with an appropriate pH value, usually around 7 - 8. Then, add the appropriate amount of sodium cholate to the buffer solution. Generally, the concentration of sodium cholate for membrane protein solubilization ranges from 0.5% to 2% (w/v), depending on the type of membrane protein. Dissolve the membrane - containing sample in the prepared sodium cholate - containing buffer, and gently stir or shake at a suitable temperature, usually 4 °C, for several hours to ensure complete solubilization. In the pharmaceutical application, when using it as an emulsifying agent for drug formulation, accurately weigh the required amount of sodium cholate according to the drug formula, and mix it with other ingredients under appropriate conditions, such as heating and stirring, to ensure uniform mixing.
Let's take a look at a case in membrane protein research. A research team was studying a specific membrane transporter protein. They used sodium cholate to solubilize the membrane proteins from the cell membrane. First, they prepared a phosphate - buffered saline (PBS) with a pH of 7.4 and added sodium cholate at a concentration of 1% (w/v). After carefully scraping the cells from the culture dish, they suspended the cells in the prepared buffer. After sonication to break the cells, they centrifuged the sample to remove cell debris. The supernatant contained the solubilized membrane proteins. Through further purification steps using chromatography, they successfully obtained a highly pure membrane transporter protein. This pure protein was then used for subsequent structure - function studies, such as X - ray crystallography and functional assays, which provided important insights into the transport mechanism of the protein.
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Este es William, CEO de Zhishang Chemical Co., Ltd.
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