High Quality niclosamide cas 50-65-7 With Best Price is a well - known chemical product. Niclosamide, with the CAS number 50 - 65 - 7, has a molecular formula of C₁₂H₄Cl₂N₂O₄. It typically appears as a yellowish - white to light yellow crystalline powder. This product is known for its high purity, which is carefully maintained during the production process to ensure optimal performance.
It has a melting point in the range of 225 - 230 °C. The density of niclosamide is about 1.76 g/cm³. The product is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone. These physical and chemical properties make it suitable for a variety of applications in different industries.
1. **Anthelmintic Treatment**: Niclosamide is widely used as an anthelmintic drug. It is highly effective against tapeworms, including Taenia saginata, Taenia solium, and Diphyllobothrium latum. By interfering with the energy metabolism of the tapeworms, it can cause them to lose their ability to attach to the intestinal wall and be expelled from the body.
2. **Molluscicide**: In the field of public health and agriculture, niclosamide is used as a molluscicide. It can control the population of snails, which are intermediate hosts for many parasites such as Schistosoma. By reducing the snail population, the spread of schistosomiasis can be effectively prevented.
3. **Biological Research**: It is also used in biological research. Niclosamide can be used to study the mechanism of cell death and autophagy pathways due to its ability to disrupt mitochondrial function in cells.
1. **Oral Administration for Anthelmintic Treatment**: When used for treating tapeworm infections in humans, the recommended dosage is usually 2 - 3 grams for adults, taken on an empty stomach. The drug should be chewed thoroughly before swallowing. It is advisable to follow up with a laxative a few hours after taking niclosamide to ensure the complete expulsion of the dead worms.
2. **Molluscicide Application**: For controlling snail populations in water bodies, niclosamide is usually formulated into a solution. The concentration of the solution depends on the size and type of the water body. Generally, a concentration of 1 - 2 ppm is used. The solution should be evenly distributed in the water to ensure effective contact with the snails.
3. **Biological Research**: In biological research, the appropriate concentration of niclosamide is determined according to the specific experimental requirements. It is usually dissolved in an appropriate organic solvent first and then diluted to the desired concentration in the cell culture medium.
1. **Anthelmintic Treatment Case**: In a rural area where tapeworm infections were common, a local medical center conducted a treatment program using niclosamide. A total of 100 patients with tapeworm infections were treated. After taking the recommended dose of niclosamide, more than 90% of the patients reported the expulsion of tapeworms within 24 hours. Follow - up stool examinations showed that the cure rate was over 85% after one - week post - treatment, indicating the high efficacy of niclosamide in tapeworm treatment.
2. **Molluscicide Case**: A wetland area was severely affected by schistosomiasis due to a large snail population. The local health department applied niclosamide solution at a concentration of 1.5 ppm. After two weeks of treatment, the snail density decreased by more than 80%. As a result, the incidence of schistosomiasis in the surrounding population also decreased significantly in the following months.
3. **Biological Research Case**: A research team was studying the autophagy pathway in cancer cells. They treated the cancer cells with different concentrations of niclosamide. Through various experimental techniques such as Western blotting and fluorescence microscopy, they found that a specific concentration of niclosamide could effectively induce autophagy in cancer cells, providing new insights for cancer research.
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