1-nitroso-2-naphthol, with the CAS number 131 - 91 - 9, is a well - known chemical compound. It is typically a yellow to orange - red crystalline powder. This compound has a molecular formula of C₁₀H₇NO₂ and a molecular weight of approximately 173.17 g/mol. The melting point of 1 - nitroso - 2 - naphthol ranges from 109 - 111 °C. It is slightly soluble in water but soluble in organic solvents such as ethanol, ether, and chloroform. The purity of our factory - supplied 1 - nitroso - 2 - naphthol can reach up to 98% or higher, ensuring high - quality for various applications.
1 - nitroso - 2 - naphthol has a wide range of applications in different fields. In the field of analytical chemistry, it is commonly used as a reagent for the determination of various metal ions. For example, it can form colored complexes with metals like cobalt, nickel, and iron, which can be detected and measured by spectrophotometric methods. These complexes are highly specific and sensitive, allowing for accurate quantification of metal ions in samples.
In the organic synthesis industry, 1 - nitroso - 2 - naphthol serves as an important intermediate. It can be used in the synthesis of various heterocyclic compounds, which are widely used in the pharmaceutical, agrochemical, and material industries. For instance, it can participate in condensation reactions to form new chemical structures with unique properties.
When using 1 - nitroso - 2 - naphthol in analytical chemistry, first, it is usually dissolved in an appropriate organic solvent to prepare a standard solution. The concentration of the solution depends on the specific analysis requirements. For example, when determining cobalt ions, a 0.1 - 1% solution of 1 - nitroso - 2 - naphthol in ethanol is commonly used. Then, the sample containing the target metal ion is added to the solution, and the reaction conditions such as pH and temperature need to be carefully controlled. The reaction usually occurs at room temperature, and the pH is adjusted to an appropriate range to ensure the formation of stable complexes.
In organic synthesis, the reaction conditions are more complex. It often requires the use of catalysts and specific reaction solvents. For example, when using 1 - nitroso - 2 - naphthol in a condensation reaction, a base catalyst such as potassium carbonate may be added, and the reaction may be carried out in an aprotic polar solvent like dimethylformamide (DMF) under reflux conditions.
Case 1: Determination of Cobalt in Environmental Water Samples
In an environmental monitoring project, a research team needed to determine the cobalt content in water samples. They first prepared a 0.5% solution of 1 - nitroso - 2 - naphthol in ethanol. The water samples were pre - treated to remove interfering substances. Then, a certain volume of the sample was added to the 1 - nitroso - 2 - naphthol solution, and the pH was adjusted to 5 - 6 using an acetate buffer. After reacting at room temperature for 15 minutes, the absorbance of the solution was measured at a wavelength of 530 nm using a spectrophotometer. By comparing with a standard curve, the cobalt content in the water samples was accurately determined. The results showed that the method using 1 - nitroso - 2 - naphthol was highly sensitive and reliable, with a detection limit of 0.01 mg/L.
Caso 2: Síntesis de un intermediario farmacéutico
A pharmaceutical company was synthesizing a new anti - inflammatory drug. 1 - nitroso - 2 - naphthol was used as an intermediate in the synthesis process. They mixed 1 - nitroso - 2 - naphthol with a specific amine compound in DMF in the presence of potassium carbonate as a catalyst. The reaction mixture was refluxed at 80 - 90 °C for 6 hours. After the reaction, the product was isolated and purified by column chromatography. The yield of the desired pharmaceutical intermediate was up to 70%, demonstrating the effectiveness of 1 - nitroso - 2 - naphthol in organic synthesis.
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