1. Descripción general del producto

Nombre del producto: 6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide

Número CAS: 342417-01-0

Fórmula molecular: C₁₉H₂₃N₄O

Peso molecular: 323.42 g/mol

Apariencia: Polvo cristalino entre blanco y blanquecino

Pureza: ≥98% (HPLC)

Almacenamiento: Store at 2-8°C in a dry, airtight container. Protect from light.

2. Aplicaciones

6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide (CAS 342417-01-0) is a high-value chemical intermediate widely used in:

• Investigación farmacéutica: Key precursor in the synthesis of kinase inhibitors and targeted cancer therapies.
• Química Orgánica: Building block for complex heterocyclic compounds.
• Biochemical Studies: Used in receptor-binding assays and enzyme inhibition studies.

3. Directrices de uso

Precauciones de seguridad

• Wear PPE (gloves, lab coat, goggles) during handling.
• Avoid inhalation or direct contact with skin/eyes.

Solubility Recommendations

• Solubilidad: Soluble en DMSO, metanol y diclorometano.
• Recommended working concentration: 10-50 mM in DMSO.

Condiciones de almacenamiento

• Stable for 24 months when stored as directed.

4. Use Case Example

Application in Kinase Inhibitor Synthesis

Paso 1: Dissolve 100 mg of CAS 342417-01-0 in 10 mL anhydrous DMSO under nitrogen atmosphere.

Segundo paso: Add 1.2 equivalents of bromo-substituted aryl reagent at 0°C.

Tercer paso: Stir at room temperature for 12 hours. Monitor reaction via TLC (ethyl acetate/hexane 3:7).

Paso 4: Purify via column chromatography to yield target kinase inhibitor (75% average yield).