Factory Supply 1-Propanesulfonyl Chloride (CAS 10147-36-1) - High Purity & Competitive Pricing

1. Información sobre el producto

1-Propanesulfonyl chloride (CAS 10147-36-1) is a sulfonating reagent widely used in organic synthesis. Key specifications include:

• Fórmula molecular: C₃H₇ClO₂S
• Peso molecular: 158.6 g/mol
• Apariencia: Líquido entre transparente y amarillo pálido
• Pureza: ≥98% (GC)
• Punto de ebullición: 220-222°C
• Densidad: 1.35 g/cm³ a 25°C
• Almacenamiento: Keep in a cool, dry place (2-8°C), protected from light and moisture.

2. Usos del producto

1-Propanesulfonyl chloride is a versatile reagent in:

• Productos farmacéuticos: Synthesis of sulfonamide drugs, antibiotics, and antiviral agents.
• Productos agroquímicos: Intermedio para herbicidas y fungicidas.
• Síntesis orgánica: Sulfonylation of amines, alcohols, and thiols to introduce the propanesulfonyl group.
• Ciencia de los materiales: Production of sulfonic acid derivatives for polymer modification.

3. Uso del producto

Handling Guidelines:

• Use in a well-ventilated fume hood with appropriate PPE (gloves, goggles, lab coat).
• Store in sealed containers under inert gas (e.g., nitrogen) to prevent hydrolysis.
• Dissolve in anhydrous solvents like dichloromethane or THF for reactions.

Reaction Example:

R-NH2 + C3H7SO2Cl → R-NH-SO2-C3H7 + HCl
        

Typical conditions: 0-5°C, slow addition to amine in presence of a base (e.g., pyridine).

4. Casos prácticos

Case Study 1: Synthesis of a Sulfonamide Drug Intermediate

• Objetivo: Prepare N-propylsulfonamide from benzylamine.
• Procedimiento: Add 1-propanesulfonyl chloride (1.2 eq) dropwise to benzylamine (1 eq) in dichloromethane at 0°C. Stir for 4 hours, wash with HCl, and isolate the product (85% yield).

Case Study 2: Agrochemical Sulfonation

• Aplicación: Modify a triazole fungicide precursor.
• Method: React with 1-propanesulfonyl chloride under alkaline conditions (pH 9-10) at 50°C for 6 hours. Purify via column chromatography.

5. Contacto

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