1. Descripción general del producto

Nombre del producto: (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester

Número CAS: 1428243-26-8

Fórmula molecular: C₁₇H₂₀BrNO₄

Peso molecular: 374.25 g/mol

Apariencia: Polvo cristalino entre blanco y blanquecino

Pureza: ≥98% (HPLC)

Almacenamiento: Store at 2-8°C in a dry, airtight container. Protect from light.

2. Aplicaciones

This compound is a high-purity chemical intermediate widely used in:

• Síntesis farmacéutica: Key intermediate in the production of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and antitumor agents.
• Organic Chemistry Research: Used to introduce ethyl and bromoacetyl functional groups into complex molecules.
• Biochemical Studies: Serves as a precursor in the development of protease inhibitors and enzyme modulators.

3. Instrucciones de uso

• Handle in a well-ventilated fume hood with appropriate PPE (gloves, lab coat, goggles).
• Store under recommended conditions to prevent degradation.
• Solubility: Soluble in DMSO, methanol, and dichloromethane. Test solubility in target solvents before large-scale use.
• For synthetic reactions, use stoichiometric ratios as per published protocols. Typical dosage: 1-2 equivalents relative to the substrate.
• Refer to the Safety Data Sheet (SDS) for detailed handling and disposal guidelines.

4. Casos prácticos

Case Study 1: Synthesis of Kinase Inhibitors

In a 2023 study, this compound was used as a critical intermediate in a 5-step synthesis of a potent kinase inhibitor. Reaction with a pyridine derivative under basic conditions yielded a 78% conversion rate, demonstrating its efficacy in forming C-N bonds.

Case Study 2: Anticancer Drug Development

A research team utilized the bromoacetyl group to create a covalent-binding analog of a HSP90 inhibitor. The ethyl-pyrrolidine moiety enhanced cellular permeability, resulting in a 40% improvement in IC₅₀ values compared to previous analogs.

5. Contacto

For pricing, bulk orders, or technical inquiries:

• Correo electrónico: info@vivalr.com
• Tel: (86) 15866781826