1. Descripción general del producto

Número CAS: 816-94-4

Nombre químico: 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC)

Fórmula molecular: C₄₄H₈₆NO₈P

Peso molecular: 788.13 g/mol

Apariencia: Polvo blanco a blanquecino

Pureza: ≥99% (HPLC)

Almacenamiento: Store at -20°C in a tightly sealed container, protected from moisture.

2. Aplicaciones y usos

DSPC is a saturated phospholipid widely used in:

• Drug Delivery: Key component in liposomal formulations for controlled release of therapeutics.
• Lipid Bilayer Research: Model membrane studies due to its high phase transition temperature (~55°C).
• Industria cosmética: Stabilizer in emulsions and nanoemulsions for skincare products.
• Gene Therapy: Enhances stability of lipid-based nucleic acid delivery systems.

3. Instrucciones de uso

Almacenamiento y manipulación

• Mantener sellado bajo gas inerte (por ejemplo, nitrógeno) para evitar la oxidación.
• Allow the product to equilibrate to room temperature before opening.

Liposome Preparation

1. Dissolve DSPC in chloroform (10 mg/mL).
2. Mix with cholesterol (molar ratio 55:45) and other lipids as required.
3. Dry using rotary evaporation to form thin film.
4. Hydrate with buffer (e.g., PBS, pH 7.4) at 60°C for 1 hour.
5. Extrude through polycarbonate membranes (100-200 nm pores).

4. Casos de aplicación

Case 1: Liposomal Doxorubicin Formulation

DSPC (40 mol%) combined with cholesterol (45 mol%) and PEG-DSPE (15 mol%) creates stealth liposomes for extended circulation of anticancer drugs. Resultado: 80% encapsulation efficiency with 72-hour serum stability.

Case 2: CRISPR-Cas9 Delivery System

Ionizable lipid/DSPC (35:55 ratio) nanoparticles achieved 90% gene editing efficiency in hepatocytes at 0.5 mg/kg dosage.

Caso 3: Formulación de una crema antiedad

3% DSPC in O/W emulsion improved retinol stability by 300% compared to traditional surfactants.

5. 5. Información de contacto

Para especificaciones técnicas o pedidos al por mayor:

• Correo electrónico: info@vivalr.com
• Tel: (86) 15866781826