The product, 2 - Amino - 5 - bromopyridine with the CAS number 1072 - 97 - 5, is presented in a high - quality form at the best price in the market. Its molecular formula is C₅H₅BrN₂, and it has a molecular weight of approximately 173.01 g/mol. The appearance of 2 - Amino - 5 - bromopyridine is typically a light - yellow to off - white crystalline powder. It has a melting point range of 108 - 112°C. This compound is sparingly soluble in water but shows good solubility in common organic solvents such as ethanol, methanol, and chloroform. High - quality 2 - Amino - 5 - bromopyridine meets strict quality control standards, ensuring high purity usually above 98%, which is determined through advanced analytical techniques like HPLC (High - Performance Liquid Chromatography) and NMR (Nuclear Magnetic Resonance) spectroscopy.
2 - Amino - 5 - bromopyridine is widely used in the field of organic synthesis. It serves as a key building block for the synthesis of various heterocyclic compounds. In the pharmaceutical industry, it is an important intermediate for the development of new drugs. For example, it can be used in the synthesis of agents with anti - inflammatory and anti - cancer potential. Due to its unique chemical structure, it can participate in a variety of chemical reactions, such as coupling reactions and substitution reactions, to create more complex and bioactive molecules. In the agrochemical industry, it can be utilized for the synthesis of pesticides and fungicides, helping to protect crops from pests and diseases. Additionally, it has applications in the field of materials science, where it can be incorporated into the synthesis of functional materials with specific optical or electrical properties.
When using 2 - Amino - 5 - bromopyridine in a laboratory or industrial setting, proper safety precautions must be taken. Wear appropriate personal protective equipment, including safety goggles, lab coats, and gloves. Store the product in a cool, dry place away from sources of heat and ignition. Before use, ensure that the reaction vessel is clean and dry. When handling the compound, use a spatula or a pipette to transfer the required amount into the reaction system. In a typical organic synthesis reaction, it is usually dissolved in an appropriate organic solvent under a controlled temperature and atmosphere. For example, in a coupling reaction, it may be mixed with a suitable catalyst and other reactants in an inert gas environment, such as nitrogen or argon. The reaction conditions, such as temperature, reaction time, and reagent ratios, should be carefully optimized according to the specific reaction requirements.
1. Pharmaceutical Synthesis:
In the synthesis of a novel anti - cancer drug, 2 - Amino - 5 - bromopyridine was used as a starting material. First, it was subjected to a palladium - catalyzed coupling reaction with an aryl boronic acid in the presence of a base in an aqueous - organic solvent mixture. The reaction was carried out at 80°C for 12 hours under a nitrogen atmosphere. After purification by column chromatography, an intermediate with a yield of 70% was obtained. This intermediate was then further reacted with other reagents through a series of steps, including acylation and cyclization, to form the final anti - cancer drug candidate. In pre - clinical studies, this drug showed significant inhibitory effects on tumor cell growth.
2. Agrochemical Synthesis:
For the synthesis of a new fungicide, 2 - Amino - 5 - bromopyridine was reacted with a chloro - substituted heterocyclic compound in the presence of a base in an organic solvent. The reaction was carried out at room temperature for 6 hours. After work - up and purification, the fungicide product was obtained with a yield of 65%. In field tests, this fungicide effectively controlled fungal diseases in wheat crops, reducing the disease incidence by up to 50% compared to untreated areas.
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