1. Descripción general del producto

3,5-Difluorophenylboronic Acid (CAS 156545-07-2) is a high-purity boronic acid derivative widely used in organic synthesis and pharmaceutical research. Key specifications include:

• Nombre químico: 3,5-Difluorophenylboronic Acid
• Número CAS: 156545-07-2
• Fórmula molecular: C₆H₅BF₂O₂
• Peso molecular: 157.91 g/mol
• Apariencia: Polvo cristalino entre blanco y blanquecino
• Pureza: ≥98% (HPLC)
• Almacenamiento: 2-8°C en un recipiente seco y hermético

2. Applications of 3,5-Difluorophenylboronic Acid

This compound is a critical reagent in:

• Suzuki-Miyaura cross-coupling reactions for C-C bond formation
• Synthesis of fluorinated pharmaceutical intermediates
• Development of agrochemicals and advanced materials
• Preparation of bioactive molecules in drug discovery

3. Directrices de uso

Recomendaciones de manipulación:

1. Use under inert atmosphere (N₂ or Ar) for moisture-sensitive reactions
2. Dissolve in polar aprotic solvents (e.g., THF, DMF) for optimal reactivity
3. Typical molar ratio: 1.0-1.2 equivalents relative to coupling partners
4. Monitor reaction progress via TLC or HPLC

Precauciones de seguridad: Wear PPE (gloves, goggles) and avoid inhalation. In case of contact, rinse thoroughly with water.

4. 4. Casos prácticos

Case 1: Synthesis of Fluorinated Biaryl Compounds

In a Suzuki coupling reaction:

• Reacted 3,5-Difluorophenylboronic Acid (1.1 eq) with 4-bromotoluene
• Catalyst: Pd(PPh₃)₄ (2 mol%)
• Base: K₂CO₃ (3 eq) in DMF/H₂O (3:1)
• Yield: 89% after 12h at 80°C

Case 2: Pharmaceutical Intermediate Preparation

Used in the synthesis of a tyrosine kinase inhibitor precursor:

• Reaction scale: 500g
• Purity of final intermediate: 99.2% (by NMR)
• Key advantage: Enhanced electron-withdrawing effect from fluorine substituents