1. Product Overview & Specifications

Nombre del producto: B-9,9′-spirobi[9H-fluoren]-2′-yl- Boronic Acid

Número CAS: 236389-21-2

Fórmula molecular: C₂₅H₁₇BO₂

Peso molecular: 360.22 g/mol

Apariencia: Polvo cristalino entre blanco y blanquecino

Pureza: ≥98% (HPLC)

Condiciones de almacenamiento: Conservar en lugar fresco y seco a 2-8°C bajo atmósfera inerte.

2. Applications of B-9,9′-spirobi[9H-fluoren]-2′-yl- Boronic Acid

This boronic acid derivative is widely used in:

• Suzuki-Miyaura Cross-Coupling Reactions: Key intermediate in synthesizing biaryl compounds for pharmaceuticals and organic electronics.
• Materiales OLED: Building block for light-emitting layers due to its rigid spirobi[fluorene] structure.
• Investigación farmacéutica: Síntesis de moléculas bioactivas y candidatos a fármacos.
• Polymer Chemistry: Monomer for creating high-performance polymers with tailored properties.

3. Directrices de uso

Precauciones de manipulación

• Use personal protective equipment (gloves, goggles, lab coat).
• Avoid exposure to moisture; handle under inert gas (e.g., nitrogen or argon).

Recommended Solvents

• THF, DMSO, or DMF for dissolution.
• Optimal reaction concentration: 0.1-0.5 M.

Condiciones de reacción

• Temperature: 60-100°C (depending on catalyst system).
• Catalysts: Pd(PPh₃)₄ or PdCl₂(dppf) recommended.

4. Casos de uso detallados

Case Study 1: OLED Material Synthesis

Objetivo: Synthesize a blue-emitting spirobi[fluorene]-based compound.

Procedimiento:

1. Mix 1.2 eq of B-9,9′-spirobi[fluoren]-2′-yl- boronic acid with 1 eq bromo-spiro[fluorene] in THF.
2. Add 0.05 eq Pd(PPh₃)₄ and 3 eq K₂CO₃ aqueous solution.
3. React at 80°C for 12 hours under nitrogen.
4. Yield: 85% after purification via column chromatography.

Caso práctico 2: Intermediario farmacéutico

Aplicación: Synthesis of a tyrosine kinase inhibitor precursor.

Proceso:

1. Couple 1 eq boronic acid with 1.1 eq aryl bromide using PdCl₂(dppf) in DMF/H₂O.
2. Heat at 90°C for 8 hours.
3. Isolate product via acid-base extraction (85% yield).

5. 5. Información de contacto

Para consultas técnicas o pedidos al por mayor:

• Correo electrónico: info@vivalr.com
• Teléfono: (86) 15866781826