Clotrimazole, with the CAS number 23593-75-1, is an antifungal medication. It belongs to the imidazole class of antifungals. The chemical formula of clotrimazole is C₂₂H₁₇ClN₂, and its molecular weight is approximately 344.83 g/mol. The product is typically available as a white to off - white crystalline powder. It is sparingly soluble in water but soluble in organic solvents such as ethanol and chloroform. This product is factory - supplied at a low price, making it a cost - effective option for various applications.
Clotrimazole has a wide range of applications. In the medical field, it is mainly used to treat fungal infections of the skin, such as athlete's foot, jock itch, and ringworm. It works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, which leads to the disruption of the cell membrane and ultimately the death of the fungus. In addition to skin infections, it can also be used to treat oral thrush when formulated as a lozenge or troche. In the pharmaceutical industry, clotrimazole is used as an active ingredient in the production of various antifungal creams, lotions, and powders. Moreover, in the research field, it can be used as a tool compound for studying fungal cell biology and the mechanism of action of antifungal drugs.
When using clotrimazole for skin infections, the affected area should be cleaned and dried thoroughly before applying the medication. A thin layer of the clotrimazole cream, lotion, or powder should be applied to the affected area and gently rubbed in. The frequency of application usually depends on the specific product and the severity of the infection, but it is commonly recommended to apply it 2 - 3 times a day. For oral thrush treatment using clotrimazole lozenges, the lozenge should be allowed to dissolve slowly in the mouth, usually 4 - 5 times a day. It is important to follow the instructions provided by a healthcare professional or the product label carefully. Do not use more or less of the product than recommended, and continue using it for the full course of treatment even if the symptoms improve before the treatment is completed to prevent the recurrence of the infection.
Case 1: Athlete's Foot Treatment
A 35 - year - old male athlete presented with symptoms of athlete's foot, including itching, redness, and scaling on his feet. He was prescribed a clotrimazole cream. After cleaning and drying his feet, he applied the cream twice a day as directed. Within the first week, the itching significantly reduced, and the redness started to fade. After two weeks of continuous use, the scaling disappeared, and the skin on his feet returned to normal. He continued using the cream for an additional week to ensure complete eradication of the fungus.
Case 2: Oral Thrush in a Child
A 5 - year - old child developed oral thrush. The pediatrician prescribed clotrimazole lozenges. The child was instructed to dissolve one lozenge in his mouth four times a day. After three days of treatment, the white patches in the mouth started to shrink. By the end of a week, the oral thrush was completely cured, and there were no signs of recurrence during the follow - up period.
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