Factory Supply N,N-Diisopropylethylamine with CAS number 7087 - 68 - 5 is a high - quality chemical product. It is also known as Hunig's base. The chemical formula of N,N - Diisopropylethylamine is C₈H₁₉N. It has a molecular weight of approximately 129.24 g/mol. This compound is a clear, colorless to pale yellow liquid with a characteristic amine odor.
It has a boiling point in the range of around 127 - 128 °C and a density of about 0.742 g/mL at 25 °C. It is soluble in common organic solvents such as ethanol, ether, and chloroform, but has limited solubility in water.
N,N - Diisopropylethylamine has a wide range of applications in the chemical industry. In organic synthesis, it is commonly used as a base. It can be used to neutralize acids generated during reactions, which is crucial in many reaction mechanisms. For example, in peptide synthesis, it helps in the activation of amino acids and the formation of peptide bonds. It can also be used in the preparation of various pharmaceutical intermediates.
In the field of polymer chemistry, it can act as a catalyst or co - catalyst in certain polymerization reactions. Additionally, it is used in the production of dyes, agrochemicals, and various specialty chemicals. It is also an important reagent in the synthesis of heterocyclic compounds.
When using N,N - Diisopropylethylamine, proper safety precautions should be taken. It should be used in a well - ventilated area, preferably under a fume hood, to avoid inhalation of its vapors. Gloves and safety goggles should be worn to prevent contact with the skin and eyes.
For small - scale laboratory use, it can be measured using a pipette or a burette. When adding it to a reaction mixture, it should be added slowly to control the reaction rate. In large - scale industrial applications, it can be transferred using appropriate pumping systems. It is important to store the product in a cool, dry place away from sources of heat and ignition.
Peptide Synthesis: In a peptide synthesis reaction, a typical setup involves dissolving the protected amino acids in an appropriate organic solvent such as N,N - dimethylformamide (DMF). N,N - Diisopropylethylamine is then added in a stoichiometric amount to deprotonate the carboxyl group of the amino acid, making it more reactive. After the addition of a coupling reagent, the reaction proceeds to form the peptide bond. For example, in the synthesis of a dipeptide, if we start with Boc - protected alanine and Fmoc - protected glycine, the addition of N,N - Diisopropylethylamine helps in the smooth formation of the alanine - glycine peptide bond.
Pharmaceutical Intermediate Synthesis: Consider the synthesis of a particular anti - inflammatory pharmaceutical intermediate. The reaction may involve the alkylation of a specific aromatic compound. N,N - Diisopropylethylamine is used as a base to abstract a proton from the aromatic compound, generating a nucleophile. This nucleophile then reacts with an alkylating agent to form the desired intermediate. The reaction conditions, such as temperature and reaction time, are carefully controlled to ensure high yields and purity of the intermediate.
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