Laurocapram, with the CAS number 59227-89-3, is a well - known chemical compound. It is also known as Azone. Laurocapram is a colorless to pale yellow, clear, oily liquid with a faint characteristic odor.
From a chemical structure perspective, it has a cyclic amide structure. The molecular formula of Laurocapram is C₁₈H₃₅NO, and its molecular weight is approximately 281.48 g/mol. It has a boiling point in the range of around 160 - 162°C at 0.13 kPa and a flash point of about 140°C. Laurocapram is soluble in many organic solvents such as ethanol, acetone, and chloroform but is insoluble in water.
Laurocapram has a wide range of applications in various industries. In the pharmaceutical industry, it is widely used as a penetration enhancer. It can increase the permeability of drugs through the skin, mucosa, and biological membranes. This property allows drugs to be absorbed more effectively, which is especially important for transdermal drug delivery systems. For example, in the development of patches for pain relief or hormone replacement therapy, Laurocapram can improve the drug's transdermal absorption rate, enhancing the therapeutic effect.
In the cosmetics industry, it can also be used as an ingredient to help active substances in cosmetics penetrate the skin more easily. This can improve the efficacy of skincare products such as anti - aging creams and moisturizers, allowing the active ingredients to reach the deeper layers of the skin and achieve better results.
When using Laurocapram, it is important to follow the recommended dosage and usage methods. In pharmaceutical formulations, the amount of Laurocapram used usually ranges from 1% - 5% of the total formulation. It should be added during the formulation process under appropriate conditions. For example, when preparing a transdermal patch, Laurocapram is typically mixed with the drug and other excipients at a controlled temperature to ensure uniform distribution.
In cosmetics, the addition amount may vary according to the type of product and the desired effect. Generally, it is used in small amounts, usually less than 3%. It should be added during the emulsification or dissolution process of the cosmetic formulation to ensure good dispersion.
Case 1: A pharmaceutical company was developing a new transdermal patch for treating arthritis pain. They added 3% Laurocapram to the patch formulation. In pre - clinical trials, compared with the patch without Laurocapram, the transdermal absorption rate of the active drug increased by 50%. In a subsequent clinical trial involving 200 patients, patients using the patch with Laurocapram reported a significant reduction in pain within 24 hours, and the overall treatment effect was better than the control group using the patch without Laurocapram.
Case 2: A skincare brand was launching a new anti - aging serum. They incorporated 2% Laurocapram into the formula. After a four - week consumer trial with 100 volunteers, 80% of the volunteers reported that the serum was more effective in reducing fine lines and wrinkles compared to the previous version of the serum without Laurocapram. The active ingredients in the serum, such as antioxidants and peptides, were able to penetrate deeper into the skin, resulting in better anti - aging effects.
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