The product we are discussing here is Potassium Bis(trimethylsilyl)amide, with the CAS number 40949-94-8. It is supplied directly from the factory and comes with the best price in the market. Chemical formula of Potassium Bis(trimethylsilyl)amide is C6H18KNSi2. Molecular weight of the product is approximately 201.47 g/mol.
It appears as a white to off - white powder under normal conditions. This product is soluble in organic solvents such as tetrahydrofuran (THF) and hexane. It should be stored in a cool, dry place away from moisture and strong oxidizing agents to maintain its stability.
Potassium Bis(trimethylsilyl)amide is widely used in the field of organic synthesis. It serves as a strong base in many chemical reactions. One of its primary applications is in deprotonation reactions. For example, it can be used to remove a proton from a weak acid in an organic molecule, facilitating subsequent reactions such as alkylation and condensation.
In the synthesis of pharmaceuticals, this compound is often used as a key reagent for the construction of complex molecular structures. It can help in the formation of carbon - carbon and carbon - heteroatom bonds, which are crucial for the development of new drugs. Additionally, it is used in the production of specialty chemicals and advanced materials where precise control of chemical reactions is required.
When using Potassium Bis(trimethylsilyl)amide, it is essential to follow proper safety procedures. First, ensure that you are working in a well - ventilated area or under a fume hood to avoid inhalation of any potentially harmful vapors. Wear appropriate personal protective equipment, including gloves and safety goggles.
To use it in a reaction, dissolve the required amount of the product in a suitable organic solvent. The choice of solvent depends on the nature of the reaction and the solubility of the reactants. Stir the solution gently to ensure complete dissolution. Then, add the other reactants slowly while maintaining the appropriate reaction temperature. After the reaction is complete, the product can be isolated and purified using standard laboratory techniques such as filtration, extraction, and chromatography.
Case 1: In a pharmaceutical research project, scientists were trying to synthesize a new anti - cancer drug. They used Potassium Bis(trimethylsilyl)amide as a base to deprotonate a specific intermediate compound. By carefully controlling the reaction conditions, they were able to selectively remove a proton and then perform an alkylation reaction. This step was crucial for the formation of the desired molecular structure. After purification, they obtained a high - yield and high - purity product, which showed promising anti - cancer activity in initial in - vitro tests.
Case 2: A materials science team was developing a new type of conductive polymer. They used Potassium Bis(trimethylsilyl)amide in a condensation reaction to link monomers together. The strong basic nature of the compound helped in promoting the reaction and controlling the degree of polymerization. As a result, they were able to produce a polymer with excellent electrical conductivity and mechanical properties, which has potential applications in flexible electronics.
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Este es William, CEO de Zhishang Chemical Co., Ltd.
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