Polyvinylpolypyrrolidone Crospovidone, also known as cross - linked PVPP, has the CAS number 25249 - 54 - 1. It is a high - quality polymer with excellent physical and chemical properties.
Physically, it is a white to off - white, free - flowing powder. It is odorless or has a very slight characteristic odor. Chemically, it is insoluble in water, ethanol, and other common organic solvents. Its cross - linked structure gives it unique swelling properties when in contact with water or other polar solvents.
The molecular weight of Crospovidone can vary depending on the manufacturing process, but it generally has a high molecular weight which contributes to its functionality. The particle size distribution is carefully controlled during production to ensure consistent performance in different applications.
In the pharmaceutical industry, Crospovidone is widely used as a disintegrant in tablets and capsules. It helps the solid dosage forms to break apart in the digestive tract, facilitating the release of the active pharmaceutical ingredients. Its excellent swelling ability and hydrophilic nature make it an ideal choice for improving the bioavailability of drugs.
In the food industry, it can be used as a clarifying agent in beverages, such as beer and wine. It helps to remove unwanted proteins and tannins, resulting in a clearer and more stable product. Additionally, it can be used as a thickener and stabilizer in some food products.
In the cosmetic industry, Crospovidone can be found in hair styling products. It provides good hold and helps to maintain the shape of the hair. It is also used in some skincare products for its ability to adsorb impurities and improve the texture of the formulations.
When using Crospovidone as a disintegrant in pharmaceuticals, it is typically added during the granulation or dry - blending process. The recommended concentration usually ranges from 2% to 5% of the total weight of the tablet or capsule formulation. The exact amount may need to be adjusted based on the characteristics of the active ingredients and the desired disintegration time.
As a clarifying agent in beverages, Crospovidone is added to the liquid during the clarification stage. It is usually used at a concentration of 0.1% - 0.5% depending on the turbidity of the beverage. After adding, it is allowed to settle, and then the clear liquid is separated from the sediment.
In hair styling products, Crospovidone is incorporated into the formulation by dissolving it in a suitable solvent or by mixing it with other ingredients under appropriate conditions. The concentration used can vary depending on the desired level of hold and the type of the product.
Case 1: A pharmaceutical company developed a new tablet formulation for a poorly soluble drug. By using Crospovidone as a disintegrant at a concentration of 3%, they were able to significantly improve the disintegration time of the tablets. In vitro dissolution tests showed that the drug release rate increased by 30% compared to the original formulation without Crospovidone. This improvement led to better bioavailability and enhanced therapeutic efficacy in clinical trials.
Case 2: A winery was facing problems with haze formation in their white wine. They decided to use Crospovidone as a clarifying agent at a concentration of 0.2%. After treatment, the wine became much clearer, and the stability of the wine improved. The sensory evaluation also showed that the flavor and aroma of the wine were not negatively affected, and the overall quality of the wine was enhanced.
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