1. Descripción general del producto

Trimethylsilylacetylene (CAS 1066-54-2) is a specialized organosilicon compound with the molecular formula C₅H₁₀Si. Key specifications include:

• Apariencia: Líquido incoloro claro
• Pureza: ≥98% (análisis GC)
• Peso molecular: 114.26 g/mol
• Punto de ebullición: 52-54°C at 760 mmHg
• Densidad: 0.763 g/mL at 25°C
• Almacenamiento: 2-8°C under inert gas

2. Aplicaciones clave

Trimethylsilylacetylene is widely used in:

• Organic synthesis of silicon-containing compounds
• Pharmaceutical intermediates for drug development
• Preparation of advanced materials in nanotechnology
• Cross-coupling reactions (e.g., Sonogashira reactions)
• Protecting group strategies in complex syntheses

3. Directrices de uso

Procedimientos de manipulación

1. Use in well-ventilated fume hood with PPE (gloves, goggles)
2. Purge reaction vessels with argon/nitrogen before use
3. Store in amber glass bottles under inert atmosphere

Condiciones de reacción

• Typical loading: 1.1-1.5 equivalents
• Compatible with THF, DMF, and dichloromethane
• Optimal temperature range: 0°C to 40°C

4. Casos prácticos

Caso 1: Síntesis de intermedios farmacéuticos

Used in 3-step synthesis of Tepotinib precursors through palladium-catalyzed coupling, achieving 82% yield with ≥99% HPLC purity.

Case 2: Semiconductor Material Development

Key component in creating silicon-acetylene hybrid polymers for OLED manufacturing, demonstrating enhanced electron mobility (15% improvement vs. standard materials).

5. 5. Información de contacto

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