N-(4-cyano-phenyl)-glycine (CAS 42288-26-6) is a specialized organic compound with the molecular formula C9H8N2O2 and a molecular weight of 176.17 g/mol. This white to off-white crystalline powder boasts a purity of ≥98% (HPLC) and is stored at 2-8°C in airtight containers to ensure stability. Its unique structure makes it a critical intermediate in pharmaceutical and chemical synthesis.
Widely used in:
Safety: Handle with PPE (gloves, goggles, lab coat) under fume hood.
Solubility: Soluble in DMF, DMSO; partially soluble in methanol.
Storage: 24-month stability in original packaging at recommended temperature.
Recommendation: Use freshly prepared solutions for optimal reactivity in coupling reactions.
Case 1: Used as key intermediate in synthesis of EGFR inhibitors, achieving 92% yield improvement compared to traditional glycine derivatives.
Case 2: Enabled development of pH-sensitive fluorescent probes through carboxyl group modification, demonstrating 40% higher photostability in cellular imaging.
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