N,N-Diethylacetamide, with the CAS number 685 - 91 - 6, is a colorless to pale - yellow liquid. It has a molecular formula of C₆H₁₃NO and a molecular weight of approximately 115.17 g/mol. This chemical is known for its good solubility in a variety of organic solvents, such as ethanol, acetone, and benzene. It has a boiling point in the range of around 185 - 187°C and a density of about 0.938 g/cm³ at 20°C. The refractive index is approximately 1.432. It is stable under normal storage conditions but should be kept away from strong oxidizing agents and acids.
1. **In the Pharmaceutical Industry**: N,N - Diethylacetamide serves as an important solvent in the synthesis of various pharmaceutical intermediates. It can dissolve many reactants, facilitating chemical reactions and improving reaction efficiency. For example, it is used in the synthesis of some anti - inflammatory drugs and antibiotics.
2. **In the Polymer Industry**: It can be used as a solvent for certain polymers, helping to control the viscosity and fluidity of polymer solutions during the manufacturing process. This is crucial for processes like film - casting and fiber - spinning, where the proper flow and distribution of polymers are essential.
3. **As an Extraction Agent**: It has the ability to extract specific compounds from mixtures. In the field of natural product extraction, it can be used to extract bioactive components from plants, such as flavonoids and alkaloids.
Handling and storage are important aspects of using N,N - Diethylacetamide. When using it in a laboratory or industrial setting, proper personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. It should be used in a well - ventilated area to prevent the inhalation of vapors.
For storage, it should be stored in a cool, dry place away from direct sunlight. The container should be tightly sealed to prevent evaporation and contamination. When transferring the product, use appropriate transfer equipment, such as a pipette or a funnel, to avoid spills.
In a reaction system, the amount of N,N - Diethylacetamide used depends on the specific reaction requirements. It is usually added in a controlled manner, and its addition rate may affect the reaction kinetics. For example, in a slow - reaction process, it may be added drop - by - drop to ensure a stable reaction environment.
Case 1: Pharmaceutical Synthesis
A pharmaceutical company was synthesizing a new anti - cancer drug. N,N - Diethylacetamide was used as a solvent in the key reaction step. By using this solvent, the reaction yield increased from 60% to 80%. The solubility of the reactants in N,N - Diethylacetamide was much better than in other solvents, which led to a more uniform reaction mixture and fewer side - reactions. The company was able to produce the drug more efficiently and at a lower cost.
Case 2: Polymer Processing
A polymer manufacturing plant was producing high - quality plastic films. They used N,N - Diethylacetamide to dissolve the polymer resin. By controlling the concentration of the polymer solution with the help of this solvent, they were able to produce films with a more uniform thickness and better mechanical properties. The solvent also improved the surface smoothness of the films, making them more suitable for applications in the packaging industry.
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