Deoxycholic acid, with the CAS number 83 - 44 - 3, is a secondary bile acid produced by intestinal bacteria acting on primary bile acids. It appears as a white to off - white crystalline powder. The molecular formula of deoxycholic acid is C₂₄H₄₀O₄, and its molecular weight is approximately 392.57 g/mol. It has a melting point in the range of 170 - 175 °C and is sparingly soluble in water, but soluble in ethanol, acetone, and acetic acid. This high - quality deoxycholic acid we offer is produced under strict quality control to ensure its purity and stability, providing you with a reliable product for various applications.
Deoxycholic acid has a wide range of applications in different fields. In the pharmaceutical industry, it is used as an emulsifier and solubilizer in drug formulations. It can enhance the solubility and bioavailability of poorly soluble drugs, which is crucial for developing effective oral and injectable medications. In addition, deoxycholic acid has been investigated for its potential therapeutic effects in treating certain liver and gallbladder diseases, as it can help regulate bile acid metabolism.
In the cosmetic industry, deoxycholic acid is used in injectable treatments for reducing submental fat (double chin). When injected into the fat tissue, it can break down the fat cells, which are then metabolized and removed from the body. This non - surgical alternative to liposuction has become increasingly popular among consumers seeking a less invasive way to improve their facial appearance.
In the field of research, deoxycholic acid is a valuable tool for studying cell membrane properties and lipid metabolism. It can be used to disrupt cell membranes and isolate membrane - associated proteins, facilitating research in biochemistry and cell biology.
**Pharmaceutical Use**: When used as an excipient in drug formulations, the appropriate amount of deoxycholic acid should be determined based on the properties of the drug and the formulation requirements. It is usually added during the manufacturing process, and strict mixing and homogenization steps should be followed to ensure uniform distribution. For injectable formulations, the solution should be filtered to remove any particulate matter before use.
**Cosmetic Use**: In cosmetic treatments for submental fat reduction, deoxycholic acid is typically administered by a trained healthcare professional through a series of injections. The treatment area is first cleansed and marked. Then, a specific volume of deoxycholic acid solution is injected into multiple sites within the fat pad. After the injection, patients may experience some swelling, bruising, or discomfort, which usually subside within a few days to weeks. Multiple treatment sessions may be required to achieve the desired results.
**Research Use**: In research laboratories, deoxycholic acid is often prepared as a stock solution in a suitable solvent. The concentration of the stock solution depends on the specific experiment. When used to treat cells, appropriate dilutions should be made to ensure that the cells are exposed to the optimal concentration of deoxycholic acid. It is important to follow proper laboratory safety procedures when handling deoxycholic acid, including wearing appropriate protective equipment.
**Case 1: Pharmaceutical Formulation**
A pharmaceutical company was developing a new oral drug for the treatment of a rare liver disease. The active ingredient of the drug was poorly soluble in water, which limited its bioavailability. By incorporating deoxycholic acid as a solubilizer in the tablet formulation, the solubility of the drug was significantly improved. In pre - clinical studies, the bioavailability of the drug in animals was increased by 30%, compared to the formulation without deoxycholic acid. This improvement in bioavailability was expected to translate into better therapeutic efficacy in human patients.
**Case 2: Cosmetic Treatment**
A 35 - year - old female patient was bothered by her double chin. She decided to undergo a deoxycholic acid injection treatment. After a series of four treatment sessions, each spaced four weeks apart, a noticeable reduction in the submental fat was observed. The patient reported an improvement in her self - esteem and facial appearance. Follow - up examinations showed that the results were maintained for at least one year after the last treatment session.
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