(Trifluoromethyl)trimethylsilane, with the CAS number 81290 - 20 - 2, is a high - quality chemical product that offers the best price in the market. Its molecular formula is C₄H₉F₃Si, and the molecular weight is approximately 142.2 g/mol. The compound appears as a colorless to light - yellow liquid under normal conditions. It has a boiling point around 53 - 54 °C and a density of about 0.956 g/mL at 25 °C. This product is known for its high purity, which ensures reliable performance in various chemical reactions.
(Trifluoromethyl)trimethylsilane is a versatile reagent widely used in organic synthesis. It is a key source of the trifluoromethyl group, which is an important structural motif in many pharmaceuticals, agrochemicals, and materials science compounds. In pharmaceutical research, the introduction of the trifluoromethyl group can significantly alter the physical, chemical, and biological properties of a molecule, such as improving lipophilicity, metabolic stability, and bioactivity. In agrochemicals, it can enhance the efficacy and environmental compatibility of pesticides and herbicides. Additionally, in materials science, it is used to modify the surface properties of polymers and other materials, providing better chemical resistance and other performance improvements.
When using (Trifluoromethyl)trimethylsilane, it is crucial to follow proper safety procedures. First, ensure that the work area is well - ventilated, preferably in a fume hood. Wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat. The product can be used in various organic solvents such as tetrahydrofuran (THF), dichloromethane, or toluene. Before use, make sure the solvents are dry to avoid unwanted side reactions. Add the (Trifluoromethyl)trimethylsilane slowly to the reaction mixture under an inert atmosphere, such as nitrogen or argon, to prevent oxidation and other unwanted reactions. The reaction conditions, such as temperature and reaction time, should be carefully controlled according to the specific reaction requirements.
Pharmaceutical Synthesis: In the synthesis of a new anti - cancer drug, (Trifluoromethyl)trimethylsilane was used to introduce a trifluoromethyl group into a key intermediate. The reaction was carried out in THF at - 78 °C under a nitrogen atmosphere. The trifluoromethylated intermediate showed improved solubility and binding affinity to the target protein, leading to enhanced anti - cancer activity in vitro and in vivo studies.
Agrochemical Development: For the development of a new herbicide, the trifluoromethyl group was introduced using (Trifluoromethyl)trimethylsilane. The resulting herbicide exhibited increased potency against a wide range of weeds while having low toxicity to non - target organisms. Field trials showed that the new herbicide effectively controlled weed growth, leading to higher crop yields.
Materials Science: In the modification of a polymer surface, (Trifluoromethyl)trimethylsilane was used to introduce a fluorine - rich layer on the polymer. The modified polymer showed improved water and oil repellency, as well as better chemical resistance. This made the polymer suitable for use in harsh environments, such as in the automotive and aerospace industries.
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