Tetrabutylammonium Hydrogen Sulfate, with the CAS number 32503-27-8, is a high - quality product available at the best price in the market. Its chemical formula is C₁₆H₃₇NO₄S. It is a white to off - white crystalline powder. The molecular weight of this compound is approximately 339.54 g/mol. It is soluble in water and common organic solvents such as ethanol and acetone. The melting point of Tetrabutylammonium Hydrogen Sulfate typically ranges from 169 - 171 °C. This product is known for its high purity, often exceeding 98%, which ensures reliable performance in various applications.
Tetrabutylammonium Hydrogen Sulfate has a wide range of applications in both research and industrial settings. In the field of analytical chemistry, it is commonly used as an ion - pairing reagent in high - performance liquid chromatography (HPLC). It helps in separating and analyzing ionic compounds by enhancing the retention and resolution of charged species. In organic synthesis, it can act as a phase - transfer catalyst. This allows reactions to occur more efficiently between reagents in different phases (e.g., between an aqueous and an organic phase), increasing the reaction rate and yield. It is also used in the preparation of certain pharmaceutical intermediates, where its ability to facilitate chemical reactions is crucial for the synthesis of complex molecules.
When using Tetrabutylammonium Hydrogen Sulfate in HPLC, first, prepare a suitable mobile phase. Dissolve an appropriate amount of the product in the mobile phase (usually water or a water - organic solvent mixture) according to the specific requirements of the analysis. The concentration typically ranges from 5 - 20 mM, but it may need to be optimized based on the analytes and column used. Filter the prepared mobile phase through a 0.45 - μm or 0.22 - μm filter to remove any particulate matter before use.
In organic synthesis as a phase - transfer catalyst, add the required amount of Tetrabutylammonium Hydrogen Sulfate to the reaction mixture. The amount usually depends on the nature and scale of the reaction, typically ranging from 1 - 10 mol% relative to the substrate. Stir the reaction mixture well to ensure proper dispersion of the catalyst and efficient phase - transfer. Monitor the reaction progress using appropriate analytical methods such as thin - layer chromatography (TLC) or high - performance liquid chromatography (HPLC).
Case 1: HPLC Analysis of Organic Acids
A research group was trying to analyze a mixture of organic acids in a complex biological sample. They used Tetrabutylammonium Hydrogen Sulfate as an ion - pairing reagent in the HPLC mobile phase. By dissolving 10 mM of the product in a water - acetonitrile (80:20 v/v) mixture, they were able to achieve excellent separation of the organic acids. The peaks were well - resolved, and the retention times were reproducible, allowing for accurate quantification of each acid in the sample.
Case 2: Organic Synthesis of a Pharmaceutical Intermediate
A pharmaceutical company was synthesizing a key intermediate for a new drug. The reaction involved a transfer of an ionic species between an aqueous and an organic phase. By adding 5 mol% of Tetrabutylammonium Hydrogen Sulfate as a phase - transfer catalyst, the reaction time was significantly reduced from several hours to less than an hour. The yield of the desired intermediate increased from 60% to over 85%, which was a major improvement in the manufacturing process.
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