Trimethoprim, with the CAS number 738 - 70 - 5, is a well - known antibacterial agent. Chemically, its molecular formula is C₁₄H₁₈N₄O₃, and it has a molecular weight of approximately 290.32 g/mol. The appearance of high - quality Trimethoprim is usually a white to off - white crystalline powder. It has a melting point range of around 199 - 203°C. This product is sparingly soluble in water, but it can dissolve in certain organic solvents such as methanol and ethanol. The high - quality Trimethoprim we offer is produced under strict quality control standards to ensure its purity and effectiveness.
Trimethoprim is primarily used in the medical and veterinary fields. In the medical industry, it is a key component in the treatment of various bacterial infections. It is often combined with sulfamethoxazole to form a synergistic antibacterial combination, which is widely used for treating urinary tract infections, respiratory tract infections, and gastrointestinal infections. The combination can block two consecutive steps in the bacterial folic acid synthesis pathway, thus inhibiting the growth and reproduction of bacteria more effectively.
In the veterinary field, Trimethoprim is also used to treat bacterial infections in animals. It can be used to treat respiratory, digestive, and urinary system infections in livestock and pets. It helps to improve the health condition of animals and prevent the spread of diseases.
When using Trimethoprim, it is crucial to follow the doctor's or veterinarian's instructions. In human medicine, the dosage of Trimethoprim usually depends on the type and severity of the infection, as well as the patient's age and overall health condition. For adults, the typical oral dose when used in combination with sulfamethoxazole is usually 160 mg of Trimethoprim and 800 mg of sulfamethoxazole every 12 hours. For children, the dosage is calculated based on body weight.
In veterinary applications, the dosage also varies according to the species, size, and condition of the animal. It can be administered orally in the form of tablets or capsules, or it can be added to the animal's feed. It is important to ensure that the animal takes the full course of treatment to achieve the best therapeutic effect.
Case 1: Urinary Tract Infection in a Human Patient
A 35 - year - old female patient presented with symptoms of frequent urination, urgency, and pain during urination. After a urine test, it was diagnosed as a urinary tract infection caused by Escherichia coli. The doctor prescribed a combination of Trimethoprim and sulfamethoxazole. The patient took the medication as directed, with a dose of 160 mg of Trimethoprim and 800 mg of sulfamethoxazole every 12 hours for 7 days. After 3 days of treatment, the patient's symptoms significantly improved, and after the full 7 - day course, the urine test showed negative for bacteria, indicating a complete recovery.
Case 2: Respiratory Infection in a Dog
A 5 - year - old Labrador retriever had symptoms of coughing, sneezing, and difficulty breathing. The veterinarian diagnosed it as a respiratory infection. The dog was given Trimethoprim orally at a dosage of 15 mg/kg body weight twice a day for 10 days. After 5 days of treatment, the dog's coughing and sneezing decreased, and its breathing became more normal. After completing the 10 - day treatment, the dog fully recovered, and its normal activity level was restored.
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