High Quality D-Tetrandrine CAS 518-34-3: Benefits, Uses, and Applications

1. Product Overview
2. Key Applications
3. Usage Guidelines
4. Detailed Use Cases
5. Contact Information

1. Product Overview

D-Tetrandrine (CAS 518-34-3) is a bisbenzylisoquinoline alkaloid derived from natural plant sources. Key specifications include:

Molecular Formula: C₃₈H₄₂N₂O₆
Molecular Weight: 622.75 g/mol
Purity: ≥98% (HPLC)
Appearance: White to off-white crystalline powder
Solubility: Soluble in DMSO, ethanol, and methanol
Storage: Store at -20°C in a dry, dark environment

2. Key Applications

D-Tetrandrine is widely utilized in pharmaceutical research and biochemical studies for:

Anti-tumor and anti-cancer mechanism studies
Anti-inflammatory and immunosuppressive research
Calcium channel blocking experiments
Hypertension and cardiovascular disease research
Natural product drug development

3. Usage Guidelines

Reconstitution & Handling

Dissolve in DMSO to prepare a 10-50 mM stock solution
Dilute with cell culture medium to achieve working concentrations (typically 1-100 μM)
Filter-sterilize solutions for cell-based assays

Important Notes

Avoid repeated freeze-thaw cycles
Use within 6 months when stored properly
Wear PPE during handling (gloves, lab coat, eye protection)

4. Detailed Use Cases

Case 1: Cancer Research Application

In a 2023 study on lung cancer cells (A549 line), researchers prepared 20 μM D-Tetrandrine solution in DMEM medium. Treatment for 48 hours resulted in:

60% inhibition of cell proliferation
Activation of apoptosis pathways (caspase-3 elevation)
Reduced tumor spheroid formation by 75%

Case 2: Anti-Inflammatory Study

For macrophage (RAW264.7) inflammation models:

10 μM D-Tetrandrine reduced LPS-induced NO production by 40%
Downregulated TNF-α expression by 55%
Optimal results achieved with pre-treatment 2h before stimulation

5. Contact Information

For technical inquiries or bulk orders:

Email: info@vivalr.com
Phone: (86) 15866781826

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About the company

Vivalr, a paragon of innovation in the chemical sector, fuses cutting - edge R & D with unwavering commitment to quality. Our product spectrum, from industrial stalwarts to fine - tuned chemicals, is a testament to our versatility.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

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FAQ

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Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

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