Specialized inFactory Supply Iodotrimethylsilane CAS 16029-98-4 With Low Priceand related product development and production

Samples: Available / Stock: Sufficient

Estimated delivery time: 3-5 days

Iodotrimethylsilane (CAS 16029-98-4) User Guide

1. Product Overview

Iodotrimethylsilane (CAS 16029-98-4) is a highly reactive organosilicon compound with the chemical formula C₃H₉ISi. Key specifications include:

Molecular Weight: 200.13 g/mol
Appearance: Colorless to pale yellow liquid
Boiling Point: 106-108°C
Density: 1.23 g/cm³ at 25°C
Storage: Store in a cool, dry, and well-ventilated area; protect from moisture and light.

2. Product Uses

Iodotrimethylsilane is widely utilized in:

Organic Synthesis: As a silylating agent for protecting hydroxyl and amino groups.
Pharmaceuticals: Intermediate in drug synthesis, particularly for activating carboxyl groups.
Polymer Chemistry: Modifying silicone-based polymers.
Carbohydrate Chemistry: Protecting sugar derivatives during glycosylation reactions.

3. Usage Instructions

Safety Precautions: Wear PPE (gloves, goggles, lab coat) and work in a fume hood.
Handling: Use anhydrous conditions to prevent hydrolysis. Transfer via syringe under inert gas (N₂ or Ar).
Reaction Setup: Add slowly to the substrate at 0-25°C. Monitor exothermic reactions.
Quenching: Neutralize excess reagent with methanol or ethanol, followed by aqueous workup.
Storage: Keep sealed under inert gas; shelf life: 12 months when stored properly.

4. Application Cases

Case 1: Synthesis of Trimethylsilyl-Protected Alcohols

Procedure: Add iodotrimethylsilane (1.2 eq) dropwise to a solution of benzyl alcohol in dry DCM at 0°C. Stir for 2 hrs at room temperature. Quench with MeOH, extract with EtOAc, and purify by column chromatography. Yield: 92%.

Case 2: Activation of Carboxylic Acids

Procedure: Mix benzoic acid (1 eq) with iodotrimethylsilane (1.5 eq) in THF. Reflux for 4 hrs. Evaporate solvent to obtain trimethylsilyl ester, used directly in peptide coupling. Conversion Rate: >95%.

5. Contact Information

For technical support or bulk orders:

Email: info@vivalr.com
Phone: (86) 15866781826

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The Manager has Something to Say

This is William, CEO of Zhishang Chemical Co., Ltd.

Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

By Air, fast but expensive.

By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

Environmental Protection Science and Technology Park, Zhengfeng Road, High-tech Zone, Jinan City, Shandong Province

Whether to provide samples?

Free samples can be provided, and customers only need to pay the corresponding shipping costs

Delivery time

There are stock in the warehouse, and some products need to be customized for production within 3 working days, depending on the workshop situation and production schedule

What payment methods and currencies are accepted here?

We accept payment methods such as TT, Western Union, and letter of credit, etc. Meanwhile, we support currencies like US dollars, euros, RMB, and Bitcoin, etc.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

User’evaluation of us

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