Our product is High Quality 5-bromoindole with the CAS number 10075-50-0. It is characterized by its low price without compromising on quality. The molecular formula of 5-bromoindole is C₈H₆BrN. It has a molecular weight of approximately 196.04 g/mol. This chemical compound appears as a light yellow to brownish crystalline powder.
5-bromoindole has a melting point in the range of 79 - 82 °C and a boiling point of around 288.6±13.0 °C at 760 mmHg. It is sparingly soluble in water but soluble in common organic solvents such as ethanol, acetone, and chloroform.
5-bromoindole is a crucial intermediate in organic synthesis. In the pharmaceutical industry, it is widely used for the synthesis of various drugs. For example, it can be used as a key starting material in the preparation of anti - cancer drugs. The unique structure of 5-bromoindole allows it to participate in a series of chemical reactions to form complex pharmaceutical molecules with specific biological activities.
In the field of materials science, 5-bromoindole is used in the synthesis of organic optoelectronic materials. These materials have potential applications in organic light - emitting diodes (OLEDs), organic photovoltaic cells (OPVs), and organic field - effect transistors (OFETs). The bromine atom in 5-bromoindole can be easily substituted by other functional groups, enabling the fine - tuning of the electronic and optical properties of the resulting materials.
When using 5-bromoindole, it is essential to follow proper safety procedures. Always wear appropriate personal protective equipment, including gloves, safety glasses, and a laboratory coat. Store the product in a cool, dry, and well - ventilated place away from sources of ignition and incompatible materials.
In a laboratory setting, when using 5-bromoindole in a chemical reaction, first, dissolve it in a suitable organic solvent. The choice of solvent depends on the specific reaction conditions. For example, if the reaction requires a polar aprotic solvent, acetonitrile or dimethylformamide (DMF) can be used. Then, carefully add other reactants and catalysts according to the reaction protocol. Monitor the reaction progress using appropriate analytical techniques such as thin - layer chromatography (TLC) or high - performance liquid chromatography (HPLC).
Pharmaceutical Synthesis Case: A research group was working on the development of a new anti - cancer drug. They used 5-bromoindole as a starting material. First, they reacted 5-bromoindole with a specific amine in the presence of a palladium catalyst under inert atmosphere conditions. The reaction was carried out in toluene at reflux temperature for several hours. After purification by column chromatography, they obtained an intermediate product with a high yield. This intermediate was then further modified through a series of reactions, including oxidation and condensation, to finally obtain the target anti - cancer drug. In vitro and in vivo tests showed that the drug had significant anti - tumor activity.
Materials Science Case: In an organic optoelectronics research project, scientists used 5-bromoindole to synthesize a new organic semiconductor material. They reacted 5-bromoindole with a thiophene derivative through a Stille coupling reaction. The resulting copolymer had good solubility in common organic solvents and showed excellent hole - transporting properties. When fabricated into an organic field - effect transistor, the device exhibited high carrier mobility and on/off current ratios, indicating its potential for applications in high - performance organic electronics.
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