Calcium dobesilate (CAS No. 20123-80-2) is a well - known pharmaceutical compound. It is the calcium salt of 2,5 - dihydroxybenzenesulfonic acid. The chemical formula of calcium dobesilate is C12H10CaO10S2. It usually appears as a white or almost white, crystalline powder.
This compound has good solubility properties. It is sparingly soluble in water and slightly soluble in methanol. The melting point of calcium dobesilate is around 280 - 285°C (decomposition). Its molecular weight is approximately 418.42 g/mol.
Calcium dobesilate is mainly used in the medical field. It has been widely recognized for its effects in improving microcirculation. In the treatment of diabetic retinopathy, it can reduce the permeability of capillaries, improve the flexibility of red blood cells, and reduce platelet aggregation. This helps to slow down the progression of retinopathy and protect the patient's vision.
It is also used in the treatment of chronic venous insufficiency. By strengthening the walls of blood vessels and improving blood flow in the veins, it can relieve symptoms such as leg heaviness, pain, swelling, and varicose veins. Additionally, it has potential applications in the treatment of some skin diseases related to microcirculation disorders.
The usage of calcium dobesilate should be strictly in accordance with the doctor's advice. Usually, it is taken orally. The dosage varies depending on the disease being treated and the patient's condition. For diabetic retinopathy, the typical daily dose may range from 500 mg to 1500 mg, divided into 2 - 3 doses. For chronic venous insufficiency, the common daily dose is around 500 - 1000 mg, also divided into multiple doses.
It is recommended to take calcium dobesilate with meals to improve its absorption and reduce the possible irritation to the stomach. During the treatment, patients should have regular follow - up examinations, including blood tests and ophthalmic examinations (if applicable), to monitor the effectiveness of the treatment and any possible side effects.
Case 1: A 55 - year - old male patient with type 2 diabetes had been diagnosed with early - stage diabetic retinopathy. After taking calcium dobesilate at a dose of 1000 mg per day for 6 months, his ophthalmic examination showed that the leakage of capillaries in the retina was significantly reduced. His visual acuity also remained stable, and the progression of retinopathy was effectively controlled.
Case 2: A 48 - year - old female with chronic venous insufficiency had suffered from leg pain and swelling for a long time. She started taking calcium dobesilate 500 mg twice a day. After 3 months of treatment, she reported a significant improvement in her symptoms. The swelling in her legs was reduced, and the heaviness and pain were much less severe, which greatly improved her quality of life.
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