Product Name: Eicosatetraynoic Acid (ETYA)
CAS Number: 1191-85-1
Molecular Formula: C₂₀H₂₈O₂
Molecular Weight: 300.4 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC analysis)
Storage: -20°C in airtight, light-sensitive containers
ETYA is a potent non-metabolizable analog of arachidonic acid, widely used in:
- Dual inhibition of lipoxygenase (LOX) and cyclooxygenase (COX) pathways
- Inflammation mechanism studies
- Lipid metabolism research
- Signal transduction pathway analysis
- Pharmacological studies of eicosanoid biosynthesis
Safety: Use PPE including nitrile gloves and safety goggles. Avoid inhalation.
Researchers applied 25 μM ETYA to macrophage cultures, demonstrating 89% suppression of leukotriene B4 production (p<0.01) through dual LOX/COX inhibition.
In a murine model, 2 mg/kg ETYA administration reduced prostaglandin E2 levels by 72% within 2 hours, validating its COX-2 inhibitory activity.
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