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User Guide for High Quality Diphenyl Azidophosphate (DPPA) CAS 26386-88-9

Table of Contents

Basic Information and Parameters

High Quality Diphenyl Azidophosphate (DPPA) with the CAS number 26386-88-9 is a high - quality chemical product available at the best price. It is a colorless to pale yellow liquid under normal conditions. The molecular formula of DPPA is C₁₂H₁₀N₃O₃P, and its molecular weight is approximately 287.20 g/mol. It has a relatively high boiling point, which makes it stable under high - temperature conditions in many chemical reactions. Its density is about 1.32 g/cm³. The product is usually stored in a cool, dry place away from direct sunlight and sources of ignition due to its chemical reactivity.

Product Uses

DPPA is widely used in organic synthesis. One of its main applications is as a coupling reagent in peptide synthesis. In the process of creating peptides, which are essential components in biological systems and pharmaceuticals, DPPA can effectively activate carboxylic acids, enabling them to react with amines to form peptide bonds. This reaction is crucial in the production of various bio - active peptides, such as hormone analogs and enzyme inhibitors.

It also serves as a phosphorylation agent in some chemical reactions. DPPA can introduce phosphate groups into organic molecules, which is significant in the synthesis of biologically important compounds like nucleotides. Additionally, it can be used in the preparation of azides, which are useful intermediates in the synthesis of heterocyclic compounds and in click chemistry reactions.

Product Usage

When using DPPA, it is essential to follow strict safety procedures. First, wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. Open the container in a well - ventilated area or under a fume hood to avoid inhalation of any potentially harmful vapors.

In peptide synthesis, typically, an equimolar amount of DPPA is added to a solution containing the carboxylic acid component. The reaction mixture is then stirred at a suitable temperature for a certain period to ensure complete activation of the acid. After that, the amine component is added, and the reaction proceeds further to form the peptide bond. The reaction conditions, such as temperature and reaction time, need to be carefully controlled according to the specific substrates and the desired product.

Product Usage Case Studies

Case 1: Peptide Synthesis for a Therapeutic Peptide
A research group was working on synthesizing a novel therapeutic peptide for treating a certain type of cancer. They used DPPA as the coupling reagent. They first dissolved the protected amino acid with a carboxylic acid group in an appropriate organic solvent, such as dichloromethane. Then, they added DPPA to the solution and stirred it for 30 minutes at 0°C to activate the carboxylic acid. Next, they added the protected amino acid with an amino group to the reaction mixture. After allowing the reaction to proceed at room temperature for 2 hours, they obtained the desired dipeptide with a high yield. Through further purification steps, they were able to isolate the pure peptide for biological testing.

Case 2: Phosphorylation Reaction
In a chemical laboratory, scientists were trying to synthesize a phosphorylated sugar derivative for studying carbohydrate - related biological processes. They used DPPA as the phosphorylation agent. They dissolved the sugar compound in a dry solvent and added DPPA under anhydrous conditions. After heating the reaction mixture at 60°C for 4 hours, they successfully introduced the phosphate group onto the sugar molecule, which was confirmed by NMR and mass spectrometry analysis.

Contact Information

If you have any questions or need further information about High Quality Diphenyl Azidophosphate (DPPA), please feel free to contact us. You can reach us via email at info@vivalr.com or call us at (86) 15866781826.

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About the company

Vivalr, a paragon of innovation in the chemical sector, fuses cutting - edge R & D with unwavering commitment to quality. Our product spectrum, from industrial stalwarts to fine - tuned chemicals, is a testament to our versatility.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
2000 square R&D center
More than 20 research and development personnel,
12 sets of research and development equipment, 10 fume hoods and 6 university laboratories have been developed in cooperation
18 patents, 140 sets of chemical synthesis processes

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
For the United States, Australia, Japan, South Korea, Sweden, France, Spain and other global more than 2000 customers to provide high-quality products and services, has won the recognition and trust of customers in the industry.

More than 12 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

Mode of Transportation

By Air, fast but expensive.

By Sea, usual and economy.

By Train, suit for middle Asia countries.

FAQ

Does it support auditing?

Environmental Protection Science and Technology Park, Zhengfeng Road, High-tech Zone, Jinan City, Shandong Province

Whether to provide samples?

Free samples can be provided, and customers only need to pay the corresponding shipping costs

Delivery time

There are stock in the warehouse, and some products need to be customized for production within 3 working days, depending on the workshop situation and production schedule

What payment methods and currencies are accepted here?

We accept payment methods such as TT, Western Union, and letter of credit, etc. Meanwhile, we support currencies like US dollars, euros, RMB, and Bitcoin, etc.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Vivalr’s delivery rate is guaranteed to be 99.99%

2000+

square meter R&D center

12+

China(set) of R&D equipment

10+

Fume hood

20+

R&D team

User’evaluation of us

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