
Tilmicosin, with the CAS number 108050 - 54 - 0, is a macrolide antibiotic. It is a semi - synthetic derivative of tylosin. High - quality tilmicosin is known for its excellent antibacterial properties. The chemical formula of tilmicosin is C₄₄H₇₄N₂O₁₄, and its molecular weight is approximately 867.06 g/mol. It usually appears as a white to off - white powder. The melting point of tilmicosin ranges from 148 - 158°C. This product is soluble in organic solvents such as methanol, ethanol, and chloroform, but has relatively low solubility in water.
Tilmicosin is widely used in the veterinary field. It has strong antibacterial activity against a variety of Gram - positive bacteria and some Gram - negative bacteria. In particular, it is highly effective against Pasteurella multocida, Mannheimia haemolytica, and Mycoplasma bovis, which are common pathogens causing respiratory diseases in cattle, sheep, and pigs. By inhibiting the synthesis of bacterial proteins, tilmicosin can effectively control the spread of these pathogens and treat respiratory tract infections, pneumonia, and other related diseases. In addition, it can also be used to prevent and treat mastitis in dairy cows, improving milk quality and dairy cattle health.
The usage of tilmicosin should be determined according to the specific situation of the animal, including the species, age, weight, and the severity of the disease. For oral administration, it can be mixed with feed or drinking water. The general dosage for cattle is 10 - 20 mg/kg body weight per day, and for pigs, it is 5 - 15 mg/kg body weight per day. When using it for injection, the dosage should be more accurately controlled under the guidance of a veterinarian. Usually, intramuscular or subcutaneous injection can be used, and the injection site should be strictly disinfected to avoid secondary infection. It is important to note that during the treatment period, the entire course of treatment must be completed as prescribed to ensure the effectiveness of the treatment and prevent the recurrence of the disease.
Case 1: Cattle Respiratory Disease
A cattle farm in the Midwest of the United States had an outbreak of respiratory disease. Many cattle showed symptoms such as coughing, nasal discharge, and reduced appetite. After laboratory testing, the pathogen was identified as Mannheimia haemolytica. The veterinarian prescribed high - quality tilmicosin for treatment. The cattle were given tilmicosin orally at a dosage of 15 mg/kg body weight per day for 5 consecutive days. After 3 days of treatment, the coughing symptoms of most cattle were significantly reduced, and after 5 days, the cattle's respiratory function basically returned to normal, and their appetite also improved.
Case 2: Pig Pneumonia
A pig farm in Europe suffered an outbreak of pneumonia. Pigs showed symptoms of high fever, shortness of breath, and listlessness. The pathogen was identified as Pasteurella multocida. Tilmicosin was administered to the pigs through drinking water at a dosage of 10 mg/kg body weight per day for 7 days. After the treatment, the mortality rate of the pigs decreased significantly, and the survival pigs gradually recovered their health, and the growth rate also returned to normal.
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